Research Personnel Publications Databases Facilities Services Training Seminars
The University of Georgia Complex Carbohydrate Research Center
Employment CCRC History Location Links Centers
 
Personnel
 Tenure-Track Faculty
 Administrative Staff
 Non Tenure-Track Faculty
 Science Staff
 Post-Doctoral Research Associates
 Graduate Students
 Undergraduate Students
Tenure-Track Faculty
Richard Steet
 Assistant Professor of Biochemistry and Molecular Biology


Bone and cartilage pathogenesis of lysosomal storage disorders using zebrafish and cell culture systems, identification of novel congenital disorders of glycosylation, developmental role of the cation-independent mannose 6-phosphate receptor

E-mail: rsteet@ccrc.uga.edu
Telephone: 706-583-5550
Fax: 706-542-4412

Short Biography
Research Interests
Publications

BCMB 8160

Short Biography:
Dr. Richard Steet received his B.A. in Biochemistry in 1994 from Colgate University and his Ph.D from the University of Colorado-Boulder in 2000. Prior to his Assistant Professor position at the University of Georgia, Dr. Steet was a Postdoctoral Fellow (2001-2005) and Instructor of Medicine (2005-2006) in the Department of Internal Medicine, Washington University School of Medicine. Full publications: 10

To Top

Research Interests:
The importance of protein glycosylation in human development has been underscored by the emergence of a group of inherited disorders known as the congenital disorders of glycosylation (CDG). Using both cell biological and biochemical approaches, our laboratory seeks to identify and characterize novel forms of these disorders with particular interest in CDGs that arise from defects in proteins that support overall Golgi function (i.e. proteins involved in vesicular trafficking events). Utilizing zebrafish as a vertebrate model organism, we are also interested in studying the craniofacial pathogenesis of lysosomal storage diseases and related genetic disorders. The goal is to delineate the cellular and molecular events that lead to the developmental defects in these patients.

To Top

Publications: Author's Last Name: Steet

Journal Articles
Book Chapters are listed at the bottom of this page.

R. Steet, S. Chung, W.S. Lee, C.W. Pine, H. Do, S. Kornfeld. 2007. Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-beta-glucosidase . Biochem. Pharmacol. 73: 1376-1383. PMID:17217920

R. Steet, S. Kornfeld. 2006. COG-7 deficient human fibroblasts exhibit altered recycling of Golgi proteins. Mol. Biol. Cell 17: 2312-2321. PMID:16510524

R. Steet, S. Chung, B. Wustman, D.A. Powell, S.H. Doares, S. Kornfeld. 2006. The iminosugar isofagomine increases the activity of N370S mutant acid-beta-glucosidase in Gaucher fibroblasts by several mechanisms. Pro. Natl. Acad. Sci. 103: 13813-13818. PMID:16945909

Book Chapters

To Top