Abu-Baker Abdel-Aal (Bak)

Visiting Graduate Student

Full name: Abu-Baker Mustafa Abdel-Aal El-Sayed

Research Interests

Design, synthesis and immunological assesment of vaccines, an area that combines the chemistry of lipids, carbohydrates and peptides as well as immunology.

Personal Information

I was born in Beni-Mazar, a small city in Upper Egypt, which is one of the oldest places in the world. The most famous cities in Upper Egypt are Luxor and Aswan, where with every footstep you can find historic sights and stories from the past.

Education

2005-present PhD student at the University of Queensland (UQ, Australia) and the Queensland Institute of Medical Research (QIMR, Australia) under supervision of Prof. Istvan Toth (UQ), Prof. Michael F. Good (QIMR), and Dr. Michael R. Batzloff (QIMR).

2003 M. Sc. in pharmaceutical organic chemistry, Assuit University, Egypt

1999 Postgraduate courses in organic chemistry, Assuit University, Egypt

1997 B. Sc. in pharmaceutical sciences, Faculty of Pharmacy, Assuit University, Egypt

Work Experience

2003-2005 Lecturer assistant in the Department of Organic Chemistry, Faculty of Pharmacy, Assuit University, Egypt

1999-2003 Demonstrator in the Department of Organic Chemistry, Faculty of Pharmacy, Assuit University, Egypt

Awards

2007 Best poster presentation at the Australian chapter of the Controlled Release Society Symposium/Annual Conference of the Australasian Pharmaceutical Science Association (AUS-CRS/APSA), Manly, Sydney (NSW, Australia)

2007 University of Queensland Graduate Scholarship Research Travel Grant

2007 Francine Kroesen Travel Fellowship

2007 Arlo D. Harris Travel Scholarship

2006 Finalist, Ausbiotech Queensland Student Awards for Excellence (ABSA 2006)

2005-present Egyptian government PhD scholarship

1998 T3A (pharmaceutical industrial company) prize for top ten pharmacy graduates

1998 Assuit state government medal for top ten university graduates

1996 Best student in the Faculty of Pharmacy, Assuit University

1992 El-Minia state government medal for top ten high school graduates

1991 El-Minia state government championship for excellent high school students

Publications

Journal articles

• Fujita, Y; Wimmer, N; Abdel-Aal, A.-B.M.; Batzloff, M.R.; Good, M.G.; Toth, I. Self-Adjuvanting glycolipopeptide vaccines: application of synthetic glycolipids as immunostimulant moieties. J. Med. Chem. 2008 (submitted).

• Simerska, P.; Abdel-Aal, A.-B. M.; Fujita, Y.; Moyle, P. M.; McGeary, R.P.; Batzloff, M. R.; Olive, C.; Good, M. F.; Toth, I. The development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines. J. Med. Chem. 2008 (accepted).

• Abdel-Aal, A.-B. M.; Batzloff, M. R.; Fujita, Y.; Barozzi, N.; Faria, A.; Simerska, P.; Moyle, P. M.; Good, M. F.; Toth, I. Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group A streptococcal vaccine candidates. J. Med. Chem. 2008, 51, 167-172.

• Simerska, P., Moyle, P. M., Zhong, W., McGeary, R., Abdel-Aal, A.-B., Good, M. F., Toth, I. : Vaccine delivery utilizing liposaccharides. BIOPOLYMERS 88 (4): 534-534 Sp. Iss. SI, 2007

• Abdel-Moty, S. G.; Abdel-Aal, A. M.; Kafafy, A. N.; El-Shorbagi, A. A. Synthesis of certain 2-aroylindole derivatives of potential analgesic, anti-inflammatory and antipyretic activities. Bulletin of Pharmaceutical Sciences, Assuit University 2005, 28, 213-223.

Conference Presentations: Oral

• Abu-Baker M. Abdel-Aal , Yoshio Fujita, Nobert Wimmer , Michael R Batzloff, Michael F. Good, Istvan Toth: Immunological assessment of novel J8-glycolipid conjugates AUS-CRS mini-symposium, Brisbane (QLD, Australia ). 1.10. 2007

• Abu-Baker M. Abdel-Aal , Yoshio Fujita, Andres Faria, Pavla Simerska, Michael R Batzloff, Michael F. Good, Istvan Toth, “Development of totally synthetic self-adjuvanting vaccines against group A streptococcus”, Proceedings of the Australasian Pharmaceutical Science Association, 3rd-5th Dec 2006, Adelaide, Australia, ISBN 0 646 44244 9 (Ed. Davey, Andrew)

• Abu-Baker M. Abdel-Aal , Istvan Toth, "Structure-activity relationship of potential self-adjuvanting vaccines against Group A streptococcus based on the carboxyl terminus of its M-protein", Brisbane Biological and Organic Chemistry Symposium (BBOCS) 2006, 24th Nov 2006, Griffith University Nathan Campus, Brisbane, Australia, ISBN 1 876731 25 7 (Ed. Todd Houston).

• Simerska P., Abdel-Aal AB., McGeary R., Moyle P.M., Fujita Y., Good M.F., Toth I. : Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection. 13th International Congress of Immunology, Rio de Janeiro ( Brazil ). 21-25.8. 2007

• Toth I., Moyle P.M., Simerska P., Fujita Y., Abdel-Aal A.B., Olive C., Good M.F.: Liposaccharides in vaccine delivery. 34th Annual Meeting & Exposition of the Controlled Release Society, Long Beach ( California, USA ) 7.-11.7. 2007

• Simerska P.: Carbohydrates as carriers in vaccine development. Group A Streptococcus vaccines AUS-CRS mini-symposium, Brisbane (QLD, Australia ). 1.10. 2007

• Toth I. , Moyle P.M., Simerska P., Fujita Y., Olive C., Good M.F.: Novel lipoamino acid based vaccine adjuvant carrier system. 13th International Congress of Immunology, Rio de Janeiro ( Brazil ). 21-25.8. 2007 (invited lecture).

• Simerska P., Moyle P.M., Abdel-Aal AB., Fujita Y., Batzloff M.R., Good M.F., Toth I.: Peptide vaccines based on carbohydrate carrier and lipidic adjuvant. The Australian Chapter of the Controlled release Society Symposium/Annual Conference of the Australasian Pharmaceutical Science Association (AUS-CRS/APSA), Manly, Sydney (NSW, Australia ). 8.-11.12. 2007

• Simerska P., Moyle P.M., Abdel-Aal AB., Fujita Y., Olive C., Batzloff M.R., Good M.F., Toth I.: Liposaccharides in peptide vaccine delivery. 4th International Peptide Symposium, Cairns (QLD, Australia ). 21.-25.10. 2007

• Fujita Y., Moyle P.M., Abdel-Aal AB., Wimmer N., Simerska P., Faria A., Hari Y., Hieu S., Batzloff M.R., Olive C., Good M.F., Toth I.: Design and Approach to Synthetic peptide-Based Subunit Vaccine. Brisbane Biological and Organic Chemistry Symposium 2007, Brisbane (QLD, Australia ). 3.12. 2007

Posters

• Abdel-Aal AB. , Fujita Y., Philipps K.S.M., Faria A., Simerska P., Batzloff M.R., Good M.F., Toth I. : The importance of epitope and lipid orientation in the design of synthetic self-adjuvanting group A streptococcal (GAS) vaccine. 4th International Peptide Symposium, Cairns (QLD, Australia ). 21.-25.10. 2007

• Abdel-Aal AB ., Zaman M., Fujita Y., Simerska P., Batzloff M.R., Good M.F., Toth I. : Towards the development of an intranasal vaccine against group A Streptococcus. The Australian Chapter of the Controlled release Society Symposium/Annual Conference of the Australasian Pharmaceutical Science Association (AUS-CRS/APSA), Manly, Sydney (NSW, Australia ). 8.-11.12. 2007

• Simerska P., Abdel-Aal AB., Fujita Y., Batzloff M.R., Good M.F., Toth I. : Multi-Epitopic Lipopeptide Group A Streptococcal Vaccine. Modern Solid Phase Peptide Synthesis & Its Applications, Port Douglas (QLD, Australia ). 17.-20.10. 2007

• Simerska P., Bong Y.K., McGeary R., Moyle P.M., Abdel-Aal AB., Good M.F., Toth I. : Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection. 13th International Congress of Immunology, Rio de Janeiro ( Brazil ) 21-25.8. 2007 (poster P1723).

• Simerska P., Bong Y., Zhong W., McGeary R., Moyle P.M., Abdel-Aal A.B., Good M.F., Toth I.: Liposaccharide Based Vaccine against Group A Streptococcal Infection. 34th Annual Meeting & Exposition of the Controlled Release Society, Long Beach ( California, USA ) 7.-11.7. 2007 (poster P278).

• Y. Fujita, A.M. Abdel-Aal, P. Simerska, A. Faria, P. Moyle, M.R. Batzloff, M. Good, I. Toth, P. Moyle, “Multi-epitopic lipid core peptide vaccine with broad protective immune responses against group A streptococcus”, 29th European Peptide Symposium, 3rd-8th Sep 2006 , Gdansk, Poland.

• Zaman M., Abdel-Aal AB., Fujita Y., Philipps K.S.M., Faria A., Simerska P., Batzloff M.R., Good M.F., Toth I.: Immunological assessment and toll-like receptor assay of a library of synthetic group A streptococcal (GAS) vaccine candidates. Brisbane Biological and Organic Chemistry Symposium 2007, Brisbane (QLD, Australia ). 3.12. 2007

• Simerska P., Abdel-Aal AB, Fujita Y., Batzloff M.R., Good M.F., Toth I. : Multi-Epitopic Lipopeptide Group A Streptococcal Vaccine. Brisbane Biological and Organic Chemistry Symposium 2007, Brisbane (QLD, Australia ). 3.12.2007

• Zaman M., Abdel-Aal AB, Fujita Y., Philipps K.S.M., Faria A., Simerska P., Batzloff M.R., Good M.F., Toth I.: Immunological assessment and toll-like receptor assay of a library of synthetic group A streptococcal (GAS) vaccine candidates. 3rd Annual SMMS Research Higher Degree Symposium, Brisbane (QLD, Australia ). 28.11. 2007

• Simerska P., Moyle P.M., Zhong W., McGeary R., Abdel-Aal A.B., Good M.F.,Toth I., ”Vaccine Delivery Utilizing Liposaccharides”, 20th American Peptide Symposium 2007 APS, Peptides for Youth, Montreal (Canada) 25.6.-1.7.2007 (poster P84).

• A. Abdel-Aal , Y. Fujita, A. Faria, P. Simerska, M. Batzloff, M. Good, I. Toth, “Design of totally synthetic self-adjuvanting vaccines against group A streptococcus”, School of Molecular and Microbial Science Research Postgraduate Symposium, 6th Dec 2006 , SMMS, University of Queensland, Brisbane, Australia.

• A. M. Abdel-Aal, S. G. abdel-Moty, A. A. El-Shorbagi, A. N. Kafafy, “ Synthesis of Certain New Indole Derivatives of Potential Anti-inflammatory, Analgesic, and Antipyretic Activity ”, 2nd international Conference on Chemistry & its Applications, University of Qatar, Doha, Qatar, December 6-9, 2003.

Thesis

• Abdel-Aal, A. M.; Abdel-Moty, S. G.; Kafafy, A. N.; El-Shorbagi, A. A., "Synthesis of certain 2-aroylindole derivatives of potential analgesic, anti-inflammatory and antipyretic activities" M. Sc., Assuit University 2003

Undergraduate and Higher Degree Candidates Supervised

Current

• Mahfuz Zaman, 2007-2008

Honors student enrolled at the School of Molecular and Microbial Science, University of Queensland (group A streptococcus vaccine project)

Past

• Andrew Lord, 2006-2007

Honors student enrolled in the School of Pharmacy, University of Queensland (group A streptococcus vaccine project)

• Khalifa Al-Isaee, 2006-2007

M. Sci. student enrolled in the School of Molecular and Microbial Science, University of Queensland (group A streptococcus vaccine project)

• Mahfuz Zaman, 2006

B. Sc. Student (undergraduate research, Biol3044) enrolled in the School of Molecular and Microbial Science, University of Queensland (group A streptococcus vaccine project)

Teaching Activities

Laboratory Demonstration and Tutoring

• Chem 1020, School of Molecular and Microbial Science, University of Queensland (2006-present)

• Chem 1030 School of Molecular and Microbial Science, University of Queensland (2006-present)

• Pharm. Org. Chem. 1, Faculty of Pharmacy, Assuit University (2000-2005)

• Pharm. Org. Chem. 2, faculty of pharmacy, Assuit University (2000-2005)

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