Selected Publications

1-- P.M. Angel, J.M. Lim, L. Wells, C. Bergmann, R. Orlando. 2007. A potential pitfall in 18O-based N-linked glycosylate site mapping. Rapid Commun. Mass Spectrom. 21: 674-682. PMID:17279607

2-- Y. Akimoto, G.W. Hart, L. Wells, K. Vosseller, K. Yamamoto, E. Munetomo, M. Ohara-Imaizumi, C. Nishiwaki, S. Nagamatsu, H. Hirano, H. Kawakami. 2007. Elevation of the post-translational modification of proteins by O-GlcNAc leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic GK rats. Glycobiology 17: 127-140. PMID:17095531

3-- K. Aoki, M. Perlman, J.M. Lim, R. Cantu, L. Wells, M. Tiemeyer. 2007. Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. J. Biol. Chem. 282: 9127-9142. PMID:17264077

4-- K. Koles, J.M. Lim, K. Aoki, M. Porterfield, M. Tiemeyer, L. Wells, V. Panin. 2007. Identification of N-glycosylated proteins ferom the central nervous system of Drosophila melanogaster. Glycobiology 17: 1388-1403. PMID:17893096

5-- L. Wells. 2007. A QUICK look at O-GlcNAc dynamics. Nat. Chem. Biol. 3: 303-304. PMID:17510643

6-- T.G. Smith, J.M. Lim, M.V. Weinberg, L. Wells, T.R. Hoover. 2007. Direct analysis of the extracellular proteome from two strains of Helicobacter phlori. Proteomics 7: 2240-2245. PMID:17533641

7-- N.G. Starostina, J.-M. Lim, M. Schvarzastein, L. Wells, A.M. Spence, E.T. Kipreos. 2007. A Cuil-2 ubiquitin ligase contains FEM-1, 2, and 3 degrades TRA-1 to regulate C. elegans sex determination. Develop. Cell 13: 127-139. PMID:17609115

8-- M. Fakhouri, M. Elalayi, D. Sherling, J.D. Hall, E. Miller, X. Sun, L. Wells, E.K. LeMosy. 2006. Minor proteins and enzymes of the Drosophila eggshell matrix. Dev. Biol. 293: 127-141. PMID:16515779

9-- B.D. Woosley, M. Xie, L. Wells., R. Orlando, D. Garrison, D. King, C. Bergmann. 2006. Comprehensive glycan analysis of recombinant Aspergillus niger-endo-polygalacturonase C. Anal. Biochem. 354: 43-53. PMID:16697346

10-- B.D. Woosley, Y.H. Kim, V.S. Kumar, L. Wells, D. King, R. Poe, R. Orlando, C. Bergmann. 2006. Complete glycan analysis of recombinant Aspergillus niger endo-polygalacturonase A. Carbohydr. Res. 341: 2370-2378. PMID:16854399

11-- K. Vosseller, K.C. Hansen, R.J. Chalkley, J.C. Trinidad, L. Wells, G.W. Hart, A.L. Burlingame. 2005. Quantitative analysis of both protein expression and serine/threonine post-translational modifications through stable isotope labeling with dithiothreitol.. Proteomics 5: 388-398. PMID:15648052

12-- Y. Akimoto, K. Yamamoto, E. Munetomo, L. Wells, K. Vosseller, G.W. Hart, H. Kawakami, H. Hirano. 2005. Elevated O-GlcNAc modification of proteins in various tissues of diabetic Goto-Kakizaki rats accompanied by diabetic complications.. Acta Histochem. Cytochem. 38: 131-142.

13-- L. Wells, L.K. Kreppel, F.I. Comer, B.E. Wadzinski, G.W. Hart. 2004. O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits . J. Biol. Chem. 279: 38466-38470. PMID:15247246

14-- M.E. Drew, J.C. Morris, Z. Wang, L. Wells, M. Sanchez, S.M. Landfear, P.T. Englund. 2003. The adenosine analog tuberciden inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library. J Biol Chem 278: 46596-46600. PMID:12972414

15-- L. Wells, G.W. Hart. 2003. O-GlcNAc turn twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar. FEBS Lett. 546: 154-158. PMID:12829252

16-- L. Wells, K. Vosseller, G.W. Hart. 2003. A role for N-acetylglucosamine s a nutrient sensor and mediator of insulin resistance. Cell Mol Life Sci 60: 222-228. PMID:12678487

17-- L. Wells, S.A. Whelan, G.W. Hart. 2003. O-GlcNAc: a regulatory post-translational modification. Biochem Biophys Res Commun 302: 435-441. PMID:12615051

18-- L. Wells, K. Vosseller, R.N. Cole, J.M. Cronshaw, M.J. Matunis, G.W. Hart. 2002. Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Mol Cell Proteomics 1: 791-804. PMID:12438562

19-- K. Vosseller, L. Wells, M.D. Lane, G.W. Hart. 2002. Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 16: 5313-5318. PMID:11959983