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Our research goals are to understand the biosynthesis, structure and function of pectin; the architecture of plant walls; how their modification can yield enhanced biomaterials including biofuel; and the structure and function of pectins with anti-cancer activity.
Recent publications:
Yin, Y., Mohnen, D., Gelineo-Albersheim, I., Xu, Y., Hahn, M.G. Glycosyltransferases of Family 8 (GT8). In Plant Cell Wall Polysaccharides: Biosynthesis and Bioengineering, Annual Plant Review series, Blackwell, Oxford, UK. (in press)
Caffal, H.K., Pattathil, S., Phillips, S.E., Hahn, M.G. and Mohnen, D. (2009) Arabidopsis thaliana T-DNA mutants implicate GAUT genes in the biosynthesis of pectin and xylan in cell walls and seed testa. Molecular Plant 2:1000-1014.
Singh, B., Avci, U., Inwood, S.E.E., Grimson,M.J., Landgraf, J., Mohnen, D., Sørensen, I., Wilkerson, C.G.W., Willats, W.G.T., and Haigler, C.H. (2009) A specialized primary wall layer conjoins cotton fibers into tissue-like bundles during elongation. Plant Physiology (Plant Physiol. 150(2):684-99.
Caffal, H.K. and Mohnen, D. (2009) The structure, function and biosynthesis of pectic polysaccharides in the context of the whole plant cell wall. Carbohydr. Res. 344:1879-1900.
Mohnen, D. (2008) Pectin Structure and Synthesis. Curr. Opin. Plant Biology 11:266-277.
Mohnen, D., Bar-Peled, M. and Somerville, C. (2008) Biosynthesis of Plant Cell Walls. In Biomass Recalcitrance, ed. Himmel, M., Blackwell Publishing, Oxford. Chapter 5, pgs. 94-187.
Etzler, M.E. and Mohnen, D. (2008) Green Plants. In Essentials of Glycobiology, Second Edition, eds. Varki, A., Cummings, R., Esko, J., Freeze, H., Stanley, P., Bertozzi, C., Hart, G. and Etzler, M. Cold Spring Harbor Laboratory Press, Chapter 22.
Jackson, C.L., Dreaden, T.M., Theobald, L.K., Tran, N.M.; Beal, T.L., Eid, M., Gao, M.Y., Shirley, R.B., Stoffel, M.T., Kumar, M.V. Mohnen, D. (2007) Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiology 17:805-819.
Persson, S., Caffall, K.H., Freshour, G. Hilley, M.T., Bauer, S., Poindexter, P., Hahn, M., Mohnen, D., Somerville, C. (2007) The Arabidopsis irregular xylem 8 mutant is deficient in glucuronoxylan and homogalacturonan which are essential for secondary cell wall integrity. Plant Cell 19:237-255.
Sterling, J.D., Atmodjo, M.A., Inwood, S.E., Kolli, V.S.K., Quigley, H.F., Hahn, M.G., and Mohnen, D. (2006) Functional identification of an Arabidopsis pectin biosynthetic homogalacturonan galacturonosyltransferase. Proc. Natl. Acad. Sci. USA.103:5236-5241.
Mohnen research featured in 'Research Highlights' from the National Research Institutes. click here for pdf.
Please click here for additional publications from the Mohnen lab.