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Parastoo Azadi
Technical Director - Analytical Services/Senior Research Scientist

Technical Director - Analytical Services

Telephone: 706-583-0629
Fax: 706-542-4412

Short Biography
Research Interests
Lab-personal web site

Lab members of Dr. Azadi's Group:
Chandralata Bal
Christian Heiss
Mayumi Ishihara
Scott Snyder

Short Biography:
Dr. Azadi received her B.Sc. in Chemistry in 1987 from University of North London, UK and her Ph.D. degree in biochemistry in 1991 from Imperial College of Science and Technology, University of London, studying structural characterization of carbohydrates and glycoproteins by mass spectrometry under the supervision of Profs. A. Dell and H.R. Morris.

In 1990 through to 1994 she was the senior scientist and the study director at M-Scan limited, an Analytical Mass Spectrometry Consultancy in UK where she was responsible for complete structural characterization of native and recombinant proteins and glycoproteins using mass spectrometry as a service to the pharmaceutical industry.

In 1994 she joined the Complex Carbohydrate Research Center as a postdoctoral fellow and studied the effect of the enzymes endohyrolase and endolyase on rhamnogalacturonan I, and characterization of the fragments produced by these enzymes by ESI-MS and ESIMS/MS. In 1996 she became the Associate Technical Director of plant and microbial Analytical Services at the Complex Carbohydrate Research Center where she was responsible for plant and microbial service program where polysaccharides and lipopolysaccharides were analyzed for other institutes.

Since 2001, Dr. Azadi has been the Technical Director of Analytical Service and Training at the Complex Carbohydrate Research Center. As the Technical Director, the she oversees and manages all analytical services and training conducted at the CCRC, which are supported by three federal resource centers of excellence that CCRC has been awarded: The Department of Energy-funded Center for Plant and Microbial Complex Carbohydrates, the National Institutes of Health Resources Center for Integrated Glycotechnology, and the National Institutes of Health for Biomedical Glycomics. The analytical service program offers two main areas of service: standard analyses and contract analyses. The samples submitted for these types of analyses come from academic, government, non-profit organizations and private companies, throughout the United States and internationally.

Dr. Azadi works closely with the research scientists in industry on developing carbohydrate based drugs and the need for out-sourcing prior to phase I and phase II clinical trials.

Her laboratory also conducts research in areas of structural characterization of plant, bacterial and animal polysaccharides, glycoproteins and glycolipids using MS and NMR techniques.

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Research Interests:
Structural analysis of oligosaccharides, glycoproteins, polysaccharides and glycolipids by mass spectrometry.

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Publications: Author's Last Name: Azadi

Journal Articles
Book Chapters are listed at the bottom of this page.

K. Talabin, C. Talabin, M. Ishihara, P. Azadi. 2018. Increased expression of the high-mannose M6N2 and NeuAc3H3N3M3N2F tri-antennary N-glycans in cholangiocarcinoma. Oncol. Lett. 15: 1030-1036. PMID:29399163

J.N. Rapicavoli, B. Blanco-Ulate, A. Muszynski, R. Figueroa-Balderas, A. Morales-Cruz, P. Azadi, J.M. Dobruchowska, C. Castro, D. Cantu, M.C. Roper. 2018. Lipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa. Nature Commun. 9: 390-390. PMID:29374171

K. Tanigaki, A. Sacharidou, J. Peng, K.L. Chambliss, I.S. Yuhanna, D. Ghosh, M. Ahmed, A.J. Szalai, W. Vongpatanasin, R.F. Mattrey, Q. Chen, P. Azadi, I. Lingvay, M. Botto, W.L. Holland, J.J. Kohler, S.R. Sirsi, K. Hoyt, P.W. Shaul, C. Mineo. 2018. Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance. J. Clin. Invest. 128: 309-322. PMID:29202472

S. Kolinko, Y.W. Wu, F. Tachea, E. Denzel, J. Hiras, R. Gabriel, N. Bäcker, L.J.G. Chan, S.A. Eichorst, D. Frey, Q. Chen, P. Azadi, P.D. Adams, T.R. Pray, D. Tanjore, C.J. Petzold, J.M. Gladden, B.A. Simmons, S.W. Singer. 2018. A bacterial pioneer produces cellulase complexes that persist through community succession. Nature Microbiol. 3: 99-107. PMID:29109478

H Flanagan-Steet, C Christian, PN Lu, M Aarnio-Peterson, L Sanman, S Archer-Hartmann, P Azadi, M Bogyo, RA Steet. 2018. TGF-Beta Regulates Cathepsin Activation during Normal and Pathogenic Development. Cell Rep. 22(11): 2964-2977. PMID:29539424

Y Chen, BA Bensing, R Seepersaud, W Mi, M Liao, PD Jeffrey, A Shajahan, RN Sonon, P Azadi, PM Sullam, TA Rapoport. 2018. Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. J Biol Chem 293(14): 5360-5373. PMID:29462788

K Shang-Guan, M Wang, NMPS Htwe, P Li, Y Li, FY Qi, D Zhang, M Cao, C Kim, H Weng, H Cen, IM Black, P Azadi, RW Carlson, G Stacey, Y Liang. 2018. Lipopolysaccharides Trigger Two Successive Bursts of Reactive Oxygen Species at Distinct Cellular Locations . Plant Physiology 176(3): 2543-2556. PMID:29431629

X Kang, A Kirui, A Muszynski, MCD Widanage, A Chen, P Azadi, P Wang, F Mentink-Vigier, T Wang. 2018. Molecular architecture of fungal cell walls revealed by solid-state NMR. Nat Commun 9(1): 2747-. PMID:30013106

H Qiu, S Shi, J Yue, M Xin, AV Nairn, L Lin, X Liu, G Li, SA Archer-Hartmann, M Dela Rosa, M Galizi, S Wang, F Zhang, P Azadi, TH van Kuppevelt, WV Cardoso, K Kimata, X Ai, KW Moremen, J Esko, RJ Linhardt, L Wang. 2018. A mutant cell library for systematic analysis of heparan sulfate. Nature Meth 15: 889-899. PMID:30377379

C.M. Woo, A. Felix, W.E. Byrd, D.K. Zuegel, M. Ishihara, P. Azadi, A.T. Iavarone, S.J. Pitteri, C.R. Bertozzi. 2017. Development of IsoTaG, a Chemical Glycoproteomics Techniques for Profiling Intact N- and O- Glycopeptides from Whole Cell Proteomes. Journal of Proteome Research 16(4): 1706-1718. PMID:28244757

E. Kintz, C. Heiss, I. Black, N. Donohue, N. Brown, M.R. Davies, P. Azadi, S. Baker, P.M. Kaye, M. van. 2017. Salmonella enterica serovar typhi lipopolysaccharide O-antigen modification impact on serum resistance and antibody recognition. Infect. Immun. 85(4): -e01021-16. PMID:28167670

M.O. Sheikh, D.F. Thieker, G. Chalmers, C.M. Schafter, M. Ishihara, P. Azadi, R.J. Woods, J.N. Glushka, B. Bendiak, J.H. Prestegard, C.M. West. 2017. 02 Sensing associated glycosylation exposes the F-box combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases. J. Biol. Chem. 46: 18897-18915. PMID:28928219

A. Amore, B.C. Knott, N.T. Supekar, A. Shajahan, P. Azadi, P. Zhao, L. Wells, J.G. Linger, S.E. Hobdey , T.A. Vander Wall, T. Shollenberger, J.M. Yarbrough, Z. Tan, M.F. Crowley, M.E. Himmel, S.R. Decker, G.T. Beckham, L.E. Taylor 2nd. 2017. Distinct roles of N- and O-glycans in cellulase activity and stability. Proc. Natl. Acad. Sci. USA 114: 13667-13672. PMID:29229855

B.S. Hamilton, J.D. Wilson, M.A. Shumakovich, A.C. Fisher, J.C. Brooks, A. Pontes, R. Naran, C. Heiss, C. Gao, R. Kardish, J. Heimburg-Molinaro, P. Azadi, R.D. Cummings, J.H. Merritt, M.P. DeLisa. 2017. A library of chemically defined human N-glycans synthesized from microbial oligosaccharide precursors. Sci. Rep. 7: 15907-15907. PMID:29162910

A. Shajahan, N.T. Supekar, C. Heiss, M. Ishihara, P. Azadi. 2017. Tool for rapid analysis of glycopeptide by permethylation via one-pot site mapping and glycan analysis. Anal. Chem. 89: 10734-10743. PMID:28921966

Y. Li, J. Fu, Y. Ling, T. Yago, J.M. McDaniel, J. Song, X. Bai, Y. Kondo, Y. Qin, C. Hoover, S. McGee, B. Shao, Z. Liu, R. Sonon, P. Azadi, J.D. Marth, R.P. McEver, C. Ruan, L. Xia. 2017. Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells. Proc. Natl. Acad. Sci. USA 114: 8360-8365. PMID:28716912

C. Matsuzaki, C. Takagaki, Y. Tomabechi, L.S. Forsberg, C. Heiss, P. Azadi, K. Matsumoto, T. Katoh, K. Hosomi, J. Kunisawa, K. Yamamoto, K. Hisa. 2017. Structural characterization of the immunostimulatory exopolysaccharide produced by Leuconostoc mesenteroides strain NTM048. Carbohydr. Res. 448: 95-102. PMID:28633071

A. Shajahan, C. Heiss, M. Ishihara, P. Azadi. 2017. Glycomic and glycoproteomic analysis of glycoproteins - a tutorial. Anal. Bioanal. Chem. 409: 4483-4505. PMID:28585084

C.L. Lowery, 3rd, C. Elliott, A. Cooper, C. Hadden, R.N. Sonon, P. Azadi, D.K. Williams, J.D. Marsh, D.S. Woulfe, F. Kilic. 2017. Cigarette smoking-associated alterations in serotonin/adrenalin signaling pathways of platelets. J. Am. Heart Assoc. 6: e005465-. PMID:28522678

U. Pachekrepapol, J.A. Lucey, Y. Gong, R. Naran, P. Azadi. 2017. Characterization of the chemical structures and physical properties of exopolysaccharides produced by various Streptococcus thermophilus strains. J. Dairy Sci. 100: 3424-3435. PMID:28318581

K Talabnin, C Talabnin, M Ishihara, P Azadi, S Wongkham, B Sripa. 2016. Differential Expression of O-glycoprotein Glycans in Cholangiocarcinoma Cell Lines. Asian Pac J Cancer Prev 17(2): 691-695. PMID:26925665

L Ma, Z Chen, W Huang, G Kutty, M. Ishihara, H. Wang, A Abouelleil, L Bishop, E Davey, R Deng, X Deng, L Fan, G Fanton, M Fitzgerald, E Gogineni, JM Goldberg, G Handley, X Hu, C Huber, X Jiao, K. Jones, JZ Levin, Y. Liu, P Macdonald, A Melnikov, C Raley, M Sassi, BT Sherman, X. Song, S Sykes, B Tran, L Walsh, W.Y. Xia, J. Yang, S Young, Q Zeng, X Zheng, R Stephens, C Nusbaum, BW Birren, P. Azadi, RA Lempicki, CA Cuomo, JA Kovacs. 2016. Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts. Nat Commun Feb 22;7: 10740-doi: 10.1038. PMID:26899007

PA Spears, EA Havell, TS Hamrick, JB Goforth, AL Levine, AS Thomas, C. Heiss, P. Azadi, PE Orndorff. 2016. Listeria monocytogenes Wall Teichoic Acid Decoration in Virulence and Cell-to-Cell Spread. Mol Microbiol Feb 12: doi:10.1111/mmi-13353. PMID:26871418

S Porfirio, MD Gomes da Silva, A. Peixe, MJ Cabrita, P Azadi. 2016. Current analytical methods for plant auxin quantification . Anal Chim Acta Jan 1; 902: 8-21. PMID:26703249

H Ito, H Kaji, A Togayachi, P Azadi, M Ishihara, R Geyer, C Galuska, H Geyer, K Kakehi, M Kinoshita, NG Karlsson, C Jin, K Kato, H Yagi, S Kondo, N Kawasaki, N Hashii, D Kolarich, K Stavenhagen, NH Packer, M Thaysen-Andersen, M Nakano, N Taniguchi, A Kurimoto, Y Wada, M Tajiri, P Yang, W Cao, H Li, PM Rudd, H Narimatsu. 2016. Comparison of analytical methods for profiling N- and O-linked glycans from cultured cell lines: HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study. Glycoconj J June; 33: 405-15. PMID:26511985

A Muszynski, C Heiss, CT Hjuler, JT Sullivan, SJ Kelly, MB Thygesen, J Stougaard, P Azadi, RW Carlson, CW Ronson. 2016. Structures of exopolysaccharides involved in receptor-mediated perception of Mesorhizobium lori by Lotus japonicus. J. Biol. Chem. jbc.m116.743856-.

A Muszynski, C Heiss, CT Hjuler, JT Sullivan, SJ Kelly, MB Thygesen, J Stougaard, P Azadi, RW Carlson, RW Ronson. 2016. Structures of exopolysaccharides involved in receptor-mediated perception of Mesorhizobium lori by Lotus japonicus. J Biol Chem Aug 8: jbc.M116.743856-. PMID:27502279

C. Zong, R. Huang, E. Condac, Y Chiu, W.Y. Xiao, X. Li, W Lu, M Ishahara, S. Wang, A. Ramiah, M Stickney, P. Azadi, IJ Amster, KW Moremen, L. Wang, JS Sharp, GJ Boons. 2016. Integrated approach to identify heparan sulfate ligand requirements of Robo1. J Am Chem Soc 138(39): 13059- 13067. PMID:27611601

KF Starr, EA Porsch, PC Seed, C Heiss, R Naran, LS Forsberg, U Amit, P Yagupsky, P Azadi, JW St Geme 3rd. 2016. Kingella kingae Expresses Four Structurally Distinct Polysaccharide Capsules that Differ in their Correlation with Invasive Disease. PLoS Pathogens 12(10): e:1005944-. PMID:27760194

N Mehta, M Porterfield, WB Struwe, C Heiss, P Azadi, PM Rudd, M Tiemeyer, K Aoki. 2016. Mass Spectrometric Quantification of N-Linked Glycans by Reference to Exogenous Standards. Journal of Proteome Research 15(9): 2969-2980. PMID:27432553

PA Spears, EA Havell, TS Hamrick, JB Goforth, AL Levine, ST Abraham, C Heiss, P Azadi, PE Orndorff. 2016. Listeria monocytogenes wall teichoic acid decoration in virulence and cell-to-cell spread. Molecular Microbiology 101(5): 714-730. PMID:26871418

L Chen, JL Valentine, CJ Huang, CE Endicott, TD Moeller, JA Rasmussen, JR Fletcher, JM Boll, JA Rosenthal, J Dobruchowska, Z Wang, C Heiss, P Azadi, D Putnam, MS Trent, BD Jones, MP DeLisa. 2016. Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies. Proceedings of the National Academy of Sciences 113(26): E3609-18. PMID:27274048

JL Valentine, L Chen, EC Perregaux, KB Weyant, JA Rosenthal, C Heiss, P Azadi, AC Fisher, D Putnam, GR Moe, JH Merritt, MP DeLisa. 2016. Immunization with Outer Membrane Vesicles Displaying Designer Glycotopes Yields Class-Switched, Glycan-Specific Antibodies. Cell Chemical Biology 23(6): 655-665. PMID:27341433

R.J. Edgar, J. Chen, S. Kant, E. Rechkina, J.S. Rush, L.S. Forsberg, B. Jaehrig, P. Azadi, V. Tchesnokova, E.V. Sokurenko, H. Zhu, K.V. Korotkov, V. Pancholi, N. Korotkova. 2016. SpyB, a small heme-binding protein, affects the composition of the cell wall in Streptococcus pyogenes. Front. Cell. Infect. Microbiol. 6: 126-. PMID:27790410

M.A. Alcantara, J. Dobruchowska, P. Azadi, B.D. Garcia, F.P. Molina-Heredia, F.M. Reyes-Sosa. 2016. Recalcitrant carbohydrates after enzymatichydrolysis of pretreated lignocellulosic biomass. Biotechnol. Biofuels 9: 207-. PMID:27713766

RP da Silva, C Heiss, IC Black, P Azadi, JQ Gerlach, LR Travassos, L Joshi, M Kilcoyne, R Puccia. 2015. Extracellular vesicles from Paracoccidioides pathogenic species transport polysaccharide and expose ligands for D-SIGN receptors. Sci Rep 5: 14213-. PMID:26387503

E Erikson, PR Wratil, M Frank, I Ambiel, K Pahnke, MP Claveria, P Azadi, N Izquierdo-Useros, H Martinez-Oucadi, C Neuer, RI Schnaar, PR Crocker, W Reuter, OT Keppler. 2015. Mouse Siglec-1 mediates trans-infection of surface-bound murine leukemia virus in sialic acid N-acyl side chain-dependent manner. J Biol Chem : -. PMID:26370074

M Zhong, H Zhang, JP Reilly, JD Christie, M Ishihara, T Kumagai, P Azadi, MP Reilly. 2015. ABO Blood Group as a Model for Platelet Glycan Modification in Arterial Thrombosis. Arterioscler Thromb Vasc Biol 35(7): 1570-1578. PMID:26044584

C Wikraiphat, N Saiprom, S Tandhavanant, C Heiss, P Azadi, G Wongsuvan, A Tuanyok, MT Holden, MN Burtnick, PJ Brett, SJ Peacock, N Chantratita. 2015. Colony Morphology Variation of Burkholderia Pseudomallei is Associated with Antigenic Variation and O-Polysaccharide Modifications. Infect Immun 83(5) : 2127-2128. PMID:25776750

G Suarez, J Romero-Gallo, M Piazuelo, G Wang, R Maier, L Forsberg, P Azadi, M Gomez, P Correa, R Peek. 2015. Modification of helicobacter pylori peptidoglycan enhances NOD1 activation and promotes cancers of the stomach. Journal of Cancer Research 75(8): 1749-1759. PMID:25732381

V.K. Köseoglu, C. Heiss, P. Azadi, E. Topchiy, Z.T. Güvener, T.E. Lehmann, K.W. Miller, M. Gomelsky. 2015. Listeria monocytogenes exopolysaccharide: Origin, structure, biosynthetic machinery and c-di-GMP-dependent regulation. Mol. Microbiol. 96(4): 728-743. PMID:25662512

N Lin, J Mascarenhas, N Sealover, H George, J Brooks, K Kayser, B Gau, I Yasa, P Azadi, S Archer-Hartmann. 2015. Chinese hamster ovary (CHO) host cell engineering to increase sialylation of recombinant therapeutic proteins by modulating sialytransferase expression. Biotechnol Prog 31(2): 334-346. PMID:25641927

C Heiss, Z Wang, I Black, P Azadi, RN Fichorova, BN Singh. 2015. Novel structural features of the immunocompetent ceramide phosphor-inositol glycan core from Trichomonas vaginalis. Carboydrate Res Jan; 419: 51-9. PMID:26671321

B. Zhang, W.Y. Xiao, H. Qiu, F. Zhang, HA Moniz, A Jaworski, E. Condac, G. Gutierrez-Sanchez, C. Heiss, RD Clugston, P. Azadi, JJ Greer, C. Bergmann, KW Moremen, D. Li, RJ Linhardt, JD Esko, L Wang. 2014. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J. Clin. Invest. 124(1): 209-221. PMID:24355925

S Piek, Z Wang, J Ganguly, AM Lakey, SN Bartley, S Mowlaboccus, A Anandan, KA Stubbs, MJ Scanlon, A Vrielink, P Azadi, RW Carlson, CM Kahler. 2014. The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin. PLoS One Sept 12: 9(9):e106513-. PMID:25215579

PJ Brennan, RV Tatituri, C Heiss, GF Watts, FF Hsu, N Veerapen, LR Cox, P Azadi, GS Besra, MB Brenner. 2014. Activation of iNKT cells by a distinct constituent of the endogenous glucosyceramide fraction. Proc Natl Acad Sci USA 111(37): 13433-8. PMID:25197085

A Yoneda, HW Kuo, M Ishihara, P Azadi, SM Yu, TH Ho. 2014. Glycosylation variants of a beta-glucosidase secreted by a Taiwanese fungus. Chaetomella raphigera, exhibit variant-specific catalytic and biochemical properties. PLoS One Sep 2;9(9): e106306-. PMID:25180973

P Kumar, C Heiss, FH Santiago-Tirado, I Black, P Azadi, TL Doering. 2014. Pbx proteins in Cryptococcus neoformans cell wall remodeling and capsule assembly. Eukaryot Cell 13(5): 560-571. PMID:24585882

JK Stone, C Heiss, Z Wang, I Black, SA Grasso, AT Koppisch, P Azadi, P Keim, A Tuanyok. 2014. Structural characterization of polysaccharides expressed by Burkholderia oklahomensis E0147. Carbohydr Res 386: 68-72. PMID:24491843

M Nasirikenari, L Veillon, CC Collins, P Azadi, JT Lau. 2014. Remodeling of marrow hematopoietic stem and progenitor cells by non-self ST6Gal-1 sialytransferase. J Biol Chem 289(10): 7178-7189. PMID:24425878

B. Zhang, W.Y. Xiao, H. Qiu, F.M. Zhang, H.A. Moniz, E. Condac, G. Gutierrez-Sanchez, C. Heiss, R.D. Clugston, P. Azadi, J.J. Greer, C. Bergmann, K.W. Moremen, D. Li, R.J. Linhardt, J.D. Esko, L. Wang. 2013. Congenital diaphragmatic hernia results from disruption of developmental angiogenesis mediated by Slit3-Robo4-heparan sulfate signaing. J. Clin. Invest. In press.

L. Meng, F. Forouhar, D. Thieker, Z. Gao, A. Ramiah, H.A. Moniz, J. Seetharaman, S. Milaninia, M. Su, R. Bridger, L. Veillon, P. Azadi, G. Kornhaber, L. Wells, G.T. Montelione, R.J. Woods, L. Tong, K.W. Moremen. 2013. Enzymatic basis for N-glycan sialylation: Structure of mammalian alpha2,6-sialytransferase (ST6GAL1) reveals conserved and unique features for glycan sialytion. J. Biol. Chem. 288(48): 34680-34698. PMID:24155237

I. Kataeva, M. Forston, S.-J. Yang, S. Pattathil, A.K. Biswal, F.L. Poole II, T.P. Thomas, P. Azadi, V. Olman, D.L. Lewis, C. Doeppke, T. Tschaplinsky, M. Davis, D. Mohnen, Y. Xu, A. Ragauskas, R.M. Kelly, M.G. Hahn, M.W.W. Adams. 2013. Extremely thermophilic bacteria exploit high temperature to deconstruct untreated plant biomass. Energy Environ. Sci. 6: 2186-2195.

FS Kittur, M Bah, S Archer-Hartmann, CY Hung, P Azadi, M Ishihara, DC Sane, J Xie. 2013. Cytoprotective effect of recombinant human erythropoietin produced in transgenic tobacco plants. PLoS One 8(10): e76468-. PMID:24124563

KF Starr, EA Porsch, C Heiss, I Black, P Azadi, JW 3rd St Geme. 2013. Characterization of the Kingella kingae polysaccharide capsule and exopolysaccharide. PLoS One 8(9): e75409-. PMID:24098695

CP Mercado, MV Quintero, Y Li, P Singh, AK Byrd, K Talabnin, M Ishihara, P Azadi, NJ Rusch, B Kuberan, L Maroteaux, F Killic. 2013. A serotonin-induced N-Glycan switch regulates platelet aggregation. Sci Rep 3: 2795-. PMID:24077408

C Heiss, MN Burtnick, RA Roberts, I Black, P Azadi, PJ Brett. 2013. Revised structures for the predominant O-polysaccharides expressed by Burkholderia pseudomallei and Burkholderia mallei. Carbohydr Res 381: 6-11. PMID:24056008

S Bubendorfer, M Ishihara, K Dohlich, C Heiss, J Vogel, F Sastre, M Panico, P Hitchen, A Dell, P Azadi, KM Thormann. 2013. Analyzing the modification of the Shewanella oneidensis MR-1 flagellar filament. PLoS One 8(9): e73444-. PMID:24039942

Y. Xu, CF Chen, TP Thomas, P. Azadi, B Diehl, CJ Tsai, N Brown, JE Carlson, M Tien, H Liang. 2013. Wood chemistry analysis and expression profiling of a poplar clone expressing a tyrosine-rich peptide. Plant Cell Rep 32(12): 1827-1847. PMID:24013761

JW Layher Jr, JS Poling, M Ishihara, P Azadi, G Alvarez-Manilla, D Puett. 2013. A Possible Effect of Concentrated Oolong Tea Causing Transient Ischemic Attack-Like Symptoms. 2013 July 18;3(4): 2157-2172. PMID:24900951

AC Bayne, D Boltz, C Owen, Y Betz, G Maia, P Azadi, S Archer-Hartmann, R Zirkle, JC Lippmeier. 2013. Vaccination against influenza with recombinant hemagglutinin expressed by Schizochytrium sp. confers protective immunity. PLoS One 8(4): e61790-doi: 10.1371. PMID:23626728

C Heiss, ML Skowyra, H Liu, JS Klutts, Z Wang, M Williams, D Srikanta, SM Beverley, P Azadi, TL Doering. 2013. Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans. J Biol Chem 288(16): 10994-11003. PMID:23408430

V.H. Pomin, Y. Park, R. Huang, C. Heiss, H,H, Sharp, P. Azadi, J.H. Prestegard. 2012. Exploiting enzyme specificities in digestions of chondroitin sulfates A and C: production of well-defined hexasaccharides. Glycobiol. 22: 826-838. PMID:22345629

E. Condac, H. Strachan, G. Gutierrez-Sanchez, B.M. Brainard, C. Giese, C. Heiss, D. Johnson, P. Azadi, C. Bergmann, R. Orlando. 2012. The C-terminal fragment of axon guidance molecular Slit3 binds heparin and neutralizes heparin anticoagulant activity. Glycobiol. 22: 1183-1192. PMID:22641771

E. Condac, H. Strachan, D. King, G. Kemp, G. Gutierrez-Sanchez, B.M. Brainard, C. Giese, C. Heiss, D. Johnson, P. Azadi, C. Bergmann, R. Orlando. 2012. SPR and differentia proteolysis/MS provide further insight into the interaction between PGIP2 and EPGs. Fungal Biol. 116: 737-746. PMID:22749160

MN Burtnick, C Heiss, AM Schuler, P Azadi, PJ Brett. 2012. Developmental of novel O-polysaccharide based glycoconjugates for immunization against glanders. Front Cell Infect Microbiol Nov 27;2:148: -.

C Heiss, MN Burtnick, I Black, P Azadi, PJ Brett. 2012. Detailed structural analysis of the O-polysaccharide expressed by Burkholderia thailandensis E264. Carbohydra Res 363: 23-28. PMID:23103510

A Cline, N Gao, H Flanagan-Steet, V Sharma, S Rosa, R Sonon, P Azadi, KC Sadler, HH Freeze, MA Lehrman, R Steet. 2012. A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency. Mol Biol Cell Nov 23(21): 4175-4187. PMID:22956764

TL Weiss, R Roth, C Goodson, S Vitha, I Black, P Azadi, J Rusch, A Holzenburg, TP Devarenne, U Goodenough. 2012. Colony Organization in the green alga Botryococcus braunii (Race B) is specified by a complex extracellular matrix. Eukaryot Cell 11(12): 1424-40. PMID:22941913

MN Burtnick, C Heiss, RA Roberts, HP Schweizer, P Azadi, PJ Brett. 2012. Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. Front Cell Infect Microbiol 2:108: doi: 10.3390-. PMID:22912938

CD Rillahan, A Antonopoulos, CT Lefort, R. Sonon, P Azadi, K Ley, A Dell, SM Haslam, JC Paulson. 2012. Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat Chem Biol 8(7): 661-668. PMID:22683610

C Heiss, MN Burtnick, Z Wang, P Azadi, PJ Brett. 2012. Structural analysis of capsular polysaccharides expressed by Burkholderia mallei and Burkholderia pseudomallei. Carbohydr Res 349: 90-94. PMID:22221792

H Zhao, J Deneau, GO Che, S Li, F Vagnini, P Azadi, R Sonon, R Ramjit, SM Lee, K Bojanowski. 2012. Angelica sinensis isolate SBD.4: composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans. Eur J Dermatol 22(1): 58-67. PMID:22146555

B Israel, ST Garner, M Thakare, D Elder, T Abney, P Azadi, JW Beach, JC Price, H Ahmed, AC Capomacchia. 2012. Transdermal permeation of noveln-acetyl-glucosamine/NSAIDs mutual prodrugs. Pharm Dev Technol 17(1): 48-54. PMID:20858066

S Gomathinayagam, T Mitchell, ER Zartler, C. Heiss, PJ Azadi, D Zha, NR Houston-Cumings, Y. Jiang, F Li, E Giaccone, RJ Porambo, CL Anderson, N Sethuraman, H. Li, TA Stadheim. 2011. Structural elucidation of an alpha-1,2-mannosidase resistant oligosaccharide produced in Pichia pastoris. Glycobiology 21(12): 1606-1615. PMID:21798867

AB Bandara, AE Champion, X Wang, G Berg, MA Apicella, M McLendon, P Azadi, DS Snyder, TJ Inzana. 2011. Isolation and mutagenesis of a capsule-like complex (CLC) from Francisella tularensis, and contribution of the CLC to F. tularensis virulence in mice. PLoS One 6(4): e19003-. PMID:21544194

VS Tagliabracci, C Heiss, C Karthik, CJ Contreras, J Glusha, M Ishihara, P Azadi, TD Hurley, AA DePaoli-Roach, PJ Roach. 2011. Phosphate incorporation during glycogen synthesis and Lafora disease. Cell Metab 2011: 274-282. PMID:21356517

C Heiss, Z Wang, P Azadi. 2011. Sodium hydroxide permethylation of heparin disaccharides. Rapid Commun Mass Spectrom 25(6): 774-778. PMID:21337639

PJ Brett, MN Burtnick, C Heiss, P Azadi, D DeShazer, DE Woods, FC Gherardini. 2011. Burkholderia thailandenis oacA mutants facilitate the expression of Burkholderia mallei-like O polysaccharides. Infect Immun 79(2): 961-969. PMID:21115721

Y. Wada, A. Dell, SM Haslam, B Tissot, K Canis, P. Azadi, M Backstrom, CE Costello, GC Hansson, Y Hiki, M. Ishihara, H Ito, K. Kakehi, N.G. Karlsson, CE Hayes, K. Kato, N. Kawasaki, KH Khoo, K Kobayashi, D. Kolarich, A Kondo, C.B. Lebrilla, M Nakano, H. Narimatsu, J Novak, MV Novotny, E Ohno, NH Packer, E Palaima, MB Renfrow, M Tajiri, KA Thomsson, H Yagi, SY Yu, N Taniguchi. 2010. Comparison of methods for profiling O-glycosylation: Human Proteome Organization Human Disease Glycomics/Proteome Initiative multi-institutional study of lgA1. Mol Cell Proteomics 9(4): 719-727. PMID:20038609

Y. Li, C. Cao, W. Jia, L. Yu, M. Lemonnier, Q. Wang, Y. Huang, J.M. Lim, M. Ishihara, L. Wells, P. Azadi, H. Robinson, Y.W. He, L. Zhang, R.A. Mariuzza. 2009. Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. EMBO J. 28: 286-297. PMID:19153605

S.T. Lee, R. Mitchell, Z. Wang, C. Heiss, D. Gardner, P. Azadi. 2009. The isolation, characterization and quantification of steroidal saponins in switchgrass (Panicum virgatum L). J. Agric. Food Chem. 57: 2599-2604. PMID:19243100

L. Chill, L. Trinh, P. Azadi, M. Ishihara, R. Sonon, E. Karnaukhova, Y. Ophir, B. Golding, J. Shiloach. 2009. Production, purification, and charcterization of human alha 1 proteinase inhibitor from Aspergillus niger. Biotechnol. Bioeng. 102: 828-844. PMID:18828177

C. Heiss, J.S. Klutts, Z. Wang, T.L. Doering, P. Azadi. 2009. The structure of Cryptococcus neoformans galactoxylomannan contains b-D-glucuronic acid. Carbohydr. Res. 344: 915-920. PMID:19345342

P. Azadi, C. Heiss. 2009. Mass spectrometry of N-linked glycans. Methods Mol. Biol. 534: 37-51. PMID:19277537

D.S. Snyder, B. Brahamsah, P. Azadi, B. Palenik. 2009. Structure and compositionally simple lipopolysaccharide from marine synechococcus. J. Bacteriol. 191: 5499-5509. PMID:19581366

M.A. Macnaughtan, F. Tian, S. Liu, L. Meng, S. Park, P. Azadi, K.W. Moremen, J.H. Prestegard. 2008. 13C-cialic acid labeling of glycans on glycoproteins using ST6Gal-1. J. Am Chem. Socl 130: 11864-11865. PMID:18700760

G. Alvarez-Manilla, N.L. Warren, T. Abney, J.A. Atwood, P. Azadi, W.S. York, M. Pierce, R. Orlando. 2007. Tools for glycomics: relative quantitation of glycans by isotopic permethylation using 13CH3I. Glycobiology 17: 677-6787. PMID:17384119

P.J. Brett, M.N. Burtnick, D.S. Synder, J.G Shannon, P. Azadi, F.C. Gherardini. 2007. Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes. Mol. Microbiol. 63: 379-290. PMID:17163980

Y. Wada, P. Azadi, C.E. Costello, A. Dell, R.A. Dwek, H. Geyer, R. Geyer, K. Kakehi, N.G. Karlsson, K. Kato, N. Kawasaki, K.H. Khoo, S. Kim, A. Kondo, E. Lattova, Y. Mechref, E. Miyoshi, K. Nakamura, H. Narimatsu, M.V. Novotny, N.H. Packer, H. Perreault, J. Peter-Katalinic, G. Pohlentz, V.N. Reinhold, P.M. Rudd, A. Suzuki`, N. Taniguchi. 2007. Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study. Glycobiology 17: 411-422. PMID:17223647

S.T. Garner,, B.J. Israel, H. Achmed, A.C. capomacchia, T. Abney, P. Azadi. 2007. Transdermal permeability of N-acetyl-D-glucosamine. Pharm. Dev. Technol. 12: 169-174. PMID:17510888

J. Li, C. Ryder, M. Mandal, F. Ahmed, P. Azadi, D.S. Snyder, R.D. Pechous, T. Zahrt, T.J. Inzana. 2007. Attenuation and protective efficacy of an O-antigen-deficient mutant of Francisella tularensis LVS. Microbiology 153: 3141-3153. PMID:17768257

D.S. Synder, D. Gibson, C. Heiss, W. Kay, P. Azadi. 2006. Structure of a capsular polysaccharide isolated from Salmonella enteritidis. Carbohydr. Res. 34: 2388-2397. PMID:16857179

P. Zhang, S. Snyder, P. Feng, P. Azadi, S. Zhang, S. Bulgheresi, K.E. Sanderson, J.-J. Cheong, J. Klena, T.-B. Chen. 2006. Role of N-acetylglucosamine within core lipopolysaccharide of several species of gram-negative bacteria in targeting the DC-SIGN (CD209). J. Immunol. 177: 4002-4011. PMID:16951363

A. Schietinger, M. Philip, B.A. Yoshida, P. Azadi, H. Liu, S.C. Meredith, H.2006 Schreiber. 2006. A mutant chaperone converts a wild-type protein into a tumor-secific antigen. Science 314: 304-308. PMID:17038624

D.L. Gibson, A.P. White, S.D. Snyder, S. Martin, C. Heiss, P. Azadi, M. Surette, W.W. Kay. 2006. Salmonela produces an O-antigen capsule regulated by AgfD and important for environmental persistence. J. Bacteriol. 188: 7722-7730. PMID:17079680

M. Kamar, G. Alvarez-Manilla, T. Abney, P. Azadi, V.S.K. Kolli, R. Orlando, K.V.S. Kolli, M. Pierce. 2004. Analysis of the site-specific N-glycosylation of b1,6N acetyl-glucosaminyltransferase V. Glycobiology 14: 583-592. PMID:15084511

M.C. Laus, T.J. Logman, A.A.N. van, R.W. Carlson, P. Azadi, M-Y. Gao, J.W. Kijne. 2004. Involvement of exo5 in production of surface polysaccharides in Rhizobium leguminosarum and its role in nodulation of Vicia sativa subsp. nigra. J. Bacteriol. 186: 6617-6625. PMID:15375143

M. Jahfar, P. Azadi. 2004. Glycosyl composition of polysaccharide from Tinospora cordifolia II. Glycosyl linkages. Acta Pharm 54: 73-78. PMID:15050047

M.L. Lawrence, M.M. Banes, P. Azadi, B.Y. Reeks. 2003. The Edwardsiella ictaluri O polysaccharide biosynthesis gene cluster and role of O polysaccharide in resistance tonormal catfish serum and catfish neutrophils. Microbiology 2003: 149-1409. PMID:1421

M.L. Williams, P. Azadi, M.L. Lawrence. 2003. Comparison of cellular and extracellular products expressed by virulent and attenuated strains of Edwardsiella ictaluri. J Aquatic Animal Health 5: 264-273.

DJ Wozniak, TJ Wyckoff, M Starkey, R Keyser, P Azadi, GA O'Toole, MR Parsek. 2003. Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci USA 100(13): 7907-7912. PMID:12810959

M.E. Marsh, A.L. Ridall, P. Azadi, P.J. Duke. 2002. Galacturonomannon and Golgu-derived membrane linked to growth and shaping of biogenic calcite. J. Struct. Biol. 139: 39-45. PMID:12372318

S. Sangadala, P. Azadi, R.W. Carlson, M. Adang. 2001. Carbohydrate analyses of Manduca sexta aminopeptidase N, co-purifying neutral lipids and their functional interactions with Bacillus thuringiensis Cry1Ac toxin. Insect Biochem. Mol. Biol. 32: 97-107. PMID:11719073

R.A. Newman, A. Cisneros, F.E. Felix, M. Vijjeswarapu, Y. Lin, P. Yang, P. Azadi. 2001. Composition and preliminary pharmacology studies. J. Herba Pharmacotherapy 1: 1-16.

K. Liab, P. Azadi, R. Collins, J. Tolan, J.S. Kim, K.-E.L. Eriksson. 2000. Relationships between activities of xylanases and xylan structures. Enzyme Microb. Technol. 27: 89-94. PMID:10862906

P. Ohana, D.P. Delmer, R.W. Carlson, J. Glushka, P. Azadi, T. Bacic, M. Benziman. 1998. Identification of a novel triterpenoid saponin from Pisum sativum as a specific inhibitor of the diguanylate cyclase of Acetobacter xylinum. Plant Cell Physiol. 39: 144-152. PMID:9559560

K.H. Khoo, E. Douglas, P. Azadi, J.M. Inamine, G.S. Besra, K. Mikusava, P.J. Brennan, D. Chaterjee. 1996. Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis: inhibition of arabinan biosynthesis by ethambutol. J. Biol. Chem. 271: 28682-28690. PMID:8910503

P. Azadi, M.A. O'Neill, C. Bergmann, A.G. Darvill, P. Albersheim. 1995. The backbone of the pectic polysaccharide rhamnogalacturonan I is fragmented by an endohydrolase and an endolyase. Glycobiology 5: 783-789. PMID:8720076

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