Research Personnel Publications Databases Facilities Services Training Seminars
The University of Georgia Complex Carbohydrate Research Center
Employment CCRC History Location Links Centers
 
Personnel
 Tenure-Track Faculty
 Administrative Staff
 Non Tenure-Track Faculty
 Science Staff
 Postdoctoral Research Associates
 Graduate Students
 Undergraduate Students
Tenure-Track Faculty
Geert-Jan Boons
Distinguished Professor in Biochemical Sciences


E-mail: gjboons@ccrc.uga.edu
Telephone: 706-542-9161
Fax: 706-542-4412

Short Biography
Research Interests
Publications
Lab-personal web site

Short Biography:
Dr. Boons received his B.S. in Chemistry in 1983 and his Ph.D. in Synthetic Carbohydrate Chemistry in 1991 from the State University of Leiden (Netherlands). Prior to joining the faculty at the CCRC in 1998, he spent seven years in the United Kingdom, first as a postdoctoral fellow at Imperial College, London, and the University of Cambridge, and then as a lecturer and professor at the University of Birmingham. In 2003, Dr. Boons was awarded the Carbohydrate Research Award for Creativity in Carbohydrate Science by the European Carbohydrate Association. Also in 2003, he was elected chairman for the 2005 Gordon Research Conference on Carbohydrates. He serves on the editorial boards of Carbohydrate Research , the Journal of Carbohydrate Chemistry , and Advances in Carbohydrate Chemistry and Biochemistry. In 2004, Dr. Boons received the Horace Isbell Award by the Division of Carbohydrate Chemistry of the American Chemical Society and was appointed Franklin Professor of Chemistry in the College of Arts and Sciences at the University of Georgia.

To Top

Research Interests:
The research of the Boons Group deals with the synthesis and biological functions of carbohydrates and glycocongugates. The diversity of topics to which the group has significantly contributed include the development of new and better methods for synthesizing exceptionally complex molecules, the use of new methods in the synthesis and study of properties of complex carbohydrates of increasing size and complexity, the development of synthetic cancer and bacterial vaccines, the design and synthesis of glycosidase inhibitors and the use of synthetic compounds for the study of innate immunity

To Top

Publications: Author's Last Name: Boons

Journal Articles
Book Chapters are listed at the bottom of this page.

Y Zhao, A Singh, Y. Xu, C. Zong, F. Zhang, GJ Boons, Z.-J. Liu, RJ Linhardt, RJ Woods, IJ Amster. 2017. Gas-phase analysis of the complex of fibroblast growth factor 1 with heparan sulfate: a traveling wave ion mobility spectrometry (TWIMS) and molecular modeling study. J Am Soc Mass Spectrom 28(1): 96-109. PMID:27663556

IA Gagarinov, T Li, JS Torano, T Caval, AD Srivastava, JAW Kruijtzer, AJR Heck, GJ Boons. 2017. Chemoenzymatic approach for the preparation of asymmetric bi-, tri- and tetra-antennary N-glycans from a common precursor. J. Am. Chem. Soc. 139(2): 1011-1018. PMID:28002670

SM Halmo, D Singh, S. Patel, S Wang, M Edlin, GJ Boons, KW Moremen, D Live, L Wells. 2017. Protein O-linked mannose beta-1,4-N-acetyglucosaminyltransferase 2 (POMGNT2) is a gatekeeper enzyme for functional glycosylation of alpha-dystroglycan. J. Biol. Chem. 292(6): 2101-2109. PMID:27932460

O Dhamale, RE Lawrence, EM Wiegmann, BA Shah, K al-Mafraji, WC Lamanna, T Lubke, T Dierks, GJ Boons, JD Esko. 2017. Arylsulfatase K is the lysosomal 2-sulfogluronate sulfatase. ACS Chem Biol 12(2): 367-373. PMID:28055182

M Movahedin, TM Brooks, NT Supekar, N Gokanapudi, GJ Boons, CL Brooks. 2017. Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen. Glycobiology 27(7): 677-687. PMID:28025250

I Agyekum, C Zong, GJ Boons, IJ Amster. 2017. Single stage tandem mass spectrometry assignment of the C-5 uronic acid stereochemistry in heparan sulfate tetrasaccharides using electron detachment dissociation . J. Am. Soc. Mass Spectrom. In press.

AE Lin, CA Autran, A Szyszka, T Escajadillo, M Huang, K Godula, AR Prudden, GJ Boons, AL Lewis, KS Doran, V Nizet, L Bode. 2017. Human milk oligosaccharides inhibit grown or group B Streptococcus. J. Biol. Chem. 292(27): 11243-11249.

AR Prudden, L Liu, CJ Capicciotti, MA Wolfert, S Wang, Z Gao, L Meng, KW Moremen, GJ Boons. 2017. Synthesis of asymmetrical multiantennary human milk oligosaccharides. Proc Natl Acad Sci USA 114(27): 6954-6959. PMID:28630345

CA Zong, A Venot, X Li, W Lu, W Xiao, JL Wilkes, CL Salanga, TM Handel, L Wang, MA Wolfert, GJ Boons. 2017. Heparan sulfate microarray reveals that heparan sulfate-protein biding exhibits different ligand requirements. J Am Chem In Press: DOI:10.1021/-.

N Ding, X Li, ZS Chinoy, GJ Boons. 2017. Synthesis of a glycosylphosphatidylinositol anchor derived from Leishmania donovani that can be functionalization by Cu-catalyzed azide-alkyne cycloadditions. Org Lett In press.

A Singh, MB Tessier, K Pederson, X. Wang, A. Venot, GJ Boons, JH Prestegard, RJ Woods. 2016. Extension and Validation of the GLYCAM Force Field Parameters for modeling Glycosaminoglycans. Canadian Journal of Chemistry 94(11): 927-935.

V Lakshminarayanan, NT Supekar, J Wei, DB McCurry, AC Dueck, HE Kosiorek, PP Trivedi, JM Bradley, CS Madsen, LB Pathangey, D Hoelzinger, MA Wolfert, GJ Boons, PA Cohen , SJ Gendler. 2016. MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice. PLoS One 11(1): e0145920-. PMID:26788922

MS Hudlikar, X Li, IA Gagarinov, N Kolishetti, MA Wolfert, GJ Boons. 2016. Controlled multi-functionalization facilitates targeted delivery of nano particles to cancer cells . Chem Eur J 22(4): 1415-1423.

S-H Yu, P Zhao, T Sun, Z Gao, KW Moremen, GJ Boons, L Wells, R Steet. 2016. Selective exo-enzymatic labeling detects increased cell surface sialoglycoprotein expression upon megakaryocytic differentiation. J. Biol. Chem. 291(8): 3982-3989. PMID:26733198

N Martinez-Saez, NT Supekar, MA Wolfert, IA Bermejo, R Hurtado-Guerrero, JL Asensio, J Jimenez-Barbero, JH Busto, A Avenoza, GJ Boons, JM Peregrina, F Corzana. 2016. Mucin architecture behind the immune response: design and evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment. Chem Eur J 7(3): 2294-2301.

P Rios, TS Carter, TJ Mooibroek, MP Crump, M Lisbjerg, M Pittelkow, NT Supekar, GJ Boons, AP Davis. 2016. Synthetic receptors for high-affinity recognition of O-GlcNAc derivatives. Angew Chem Int Ed 55(10): 3387-3392. PMID:26822115

T Fang, Y Gu, W Huang, GJ Boons. 2016. Mechanism of glycosylation of anomeric sulfonium ions. J Am Chem Soc 138(9): 3002-3011. PMID:26878147

K Wang, F. Friscourt, CT Dai, L Wang, Y Zheng, GJ Boons, S Wang, BS Wang. 2016. A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides. Bioorg Medicinal Chem Lett 26(7): 1651-1654. PMID:26944613

R Huang, C Zong, A Venot, Y Chiu, D Zhou, GJ Boons, JS Sharp. 2016. De novo sequencing of complex mixtures of heparan sulfate oligosaccharides. Anal Chem 88(10): 5299-5307. PMID:27087275

MJG Bakkers, Q Zeng, LJ Feitsma, RJG Hulswit, Z Li, A Westerbeke, FJM van Kuppeveld, GJ Boons, MA Langereis, EG Huizinga, RJ de Groot. 2016. Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation. Proc Natl Acad Sci USA 113(22): E3111-E3119. PMID:27185912

X. Li, SJH Martin, ZS Chinoy, L.H. Liu, B Rittgers, RA Dluhy, GJ Boons. 2016. Label free detection of glycan-protein interactions for array development by surface enhanced Raman spectroscopy (SERS). Chem Eur J 22(32): 11180-11185. PMID:27304194

L Bode, NT Contractor, D Barile, N Pohl, A.R. Prudden, GJ Boons, Y-S Jin, S Jennewein. 2016. Approaches to overcome the limited availability of human milk oligosacharides: Challenges and opportunities for research and application. Nutr Reve 74(10): 635-644. PMID:27634978

T Sun, Yu S-H, P Zhao, L Meng, KW Moremen, L Wells, R Steet, GJ Boons. 2016. One-step selective exoenzymatic labeling (SEEL) strategy for the biotinylation and identification of glycoproteins of living cells. J Am Chem Soc 138(36): 11575-11582. PMID:27541995

C. Zong, R. Huang, E. Condac, Y Chiu, W.Y. Xiao, X. Li, W Lu, M Ishahara, S. Wang, A. Ramiah, M Stickney, P. Azadi, IJ Amster, KW Moremen, L. Wang, JS Sharp, GJ Boons. 2016. Integrated approach to identify heparan sulfate ligand requirements of Robo1. J Am Chem Soc 138(39): 13059- 13067. PMID:27611601

Q Gao, C-Y Chen, CT Zong, S. Wang, A. Ramiah, P Prabhakar, L.C. Morris, GJ Boons, K. Moremen, J.H. Prestegard. 2016. Structural aspects of heparan sulfate binding to Robo1-lg1-2. ACS Chem Biol 11(11): 3106-3113. PMID:27653286

T Li, M Huang, L Liu, S Wang, KW Moremen, GJ Boons. 2016. Divergent chemoenzymatic synthesis of asymmetrical core fucosylated and core-unmodified N-glycans. Chem - Eur J 22(52): 18742-18746. PMID:27798819

SH Yu, P Zhao, T Sun, Z Gao, KW Moremen, GJ Boons, L Wells, R Steet. 2016. Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression upon Megakaryocytic Differentiation. J Biol Chem 29(18): 3982-3989. PMID:26733198

Y Huang, Y Mao, C Zhong, C Lin, GJ Boons, J Zaia. 2015. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Anal. Chem. 87(1): 592-600. PMID:25486437

CL Forestier, Q Gao, GJ Boons. 2015. Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?. Front. Cell. Infect. Microbiol. 4:193: 1-7. PMID:25653924

IA Gagarinov, T Fang, L Liu, AD Srivastava, GJ Boons. 2015. Synthesis of Staphylococcus aureus Type 5 trisaccharide repeating unit: solving the problem of lactamization. Org Lett 17(4): 928-931. PMID:25658811

P Thompson, V Lakshminarayanan, NT Supekar, JM Bradley, PA Cohen, MA Wolfert, SJ Gendler, GJ Boons. 2015. Linear synthesis and immunological properties of a fully synthetic vaccine containing a sialylated MUC1 glycopeptide. Chem Commun 51(50): 10214-10217. PMID:26022217

ZS Chinoy, CM Schafer, CM West, GJ Boons. 2015. Chemical synthesis of a glycopeptide derived from Skp1 for probing protein specific glycosylation. Chem Eur J 21(33): 11779-11787. PMID:26179871

LH Liu, J Zha, AF DiGiandomenico, D McAllister, CK Stover, Q. Wang, GJ Boons. 2015. Synthetic enterobacterial common antigen (ECA) for the development of a universal immunotherapy for drug-resistant Enterobacteriaceae. Angew Chem Int Ed 54(37): 10953-10957. PMID: 26216389

F Friscourt, CJ Fahrni, GJ Boons. 2015. Fluorogenic strain-promoted alkyne-diazo cycloadditions. Chemistry 21(40): 13996-14001. PMID:26330090

W Huang, Q Gao, GJ Boons. 2015. Assembly of a complex branched oligosaccharide by combining fluorous-supported synthesis and stereoselective glycosylations using anomeric sulfonium ions. Chem Eur J 21(37): 12920-12926. PMID:26250358

PA Ledin, W Xu, FH Friscourt, GJ Boons, V Tsukruk. 2015. Branched polyhedral oligomeric silsesquioxane nano particles prepared via strain-promoted 1.3-dipolar cycloadditions. Langmuir 31(29): 8146-8155. PMID:26131712

I Agyekum, AB Patel, CL Zong, GJ Boons, IJ Amster. 2015. Assignment of hexuronic acid stereochemistry in synthetic heparan sulfate tetrasaccharides with 2-0-sulfouronic acids using electron detachment dissociation. Int J Mass Spectrom 390: 163-169. PMID:26612977

SL van der Beek, Y Le Breton, AT Ferenbach, RN Chapman, DMF van Aalten, I Navratilova, GJ Boons, KS McIver, NM van Sorge, HC Dorfmueller. 2015. GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmID). Mol Microbiol 98(5): 946-962. PMID:26278404

M.J. Kailemia, M. Park, D.A. Kaplan, A. Venot, G.J. Boons, L. Li, R.J. Linhardt, I.J. Amster. 2014. High-field asymmetric-waveform ion mobility spectrometry and electron detachment dissociation for isobaric mixtures of glycosaminoglycans. J. Am. Soc. Mass Spectrom. 25(2): 258-268. PMID:24254578

O.P. Dhamale, C. Zhong, K. Al-Mafraji, G.J. Boons. 2014. New glucuronic acid donors for the modular synthesis of heparan sulfate oligosaccharides. Org Biomol Chem Issue 12 (13): 2087-2098. PMID:24549353

S. Arumugam, J. Guo, N.E. Mbua, F. Friscourt, N. Lin, E. Nekongo, G.J. Boons, V.V. Popik. 2014. Selective and reversible photochemical derivatization of cysteine residues in peptides and proteins. Chem. Sci. 5(4): 1591-1598. PMID:24765521

P.A. Ledin, N. Kolishetti, M.S. Hudlikar, G.J. Boons. 2014. Exploring strain-promoted 1,3-dipolar cycloadditions on end functionalized polymers. Chem - Eur J 20(28): 8753- 8760. PMID:24906200

A.M. Abdel, V. Lakshminarayanan, P. Thompson, N. Supekar, J.M. Bradley, M.A. Wolfert, P.A. Cohen, S.J. Gendler, G.J. Boons. 2014. Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUCI1 tripartite vaccines modified by a TLR2 or TLR9 agonist. ChemBioChem 15(10): 1508-1513. PMID:24890740

X. Li, T. Fang, G.J. Boons. 2014. Preparation of well-defined antibody-drug conjugates through glycan remodeling and strain promoted azide-alkyne cycloadditions. Angew. Chem. Int. Ed. 53(28): 7179-7182. PMID:24862406

A.R. Prudden, Z.S. Chinoy, M.A. Wolfert, G.J. Boons. 2014. A multifunctional anomeric linker for the chemo enzymatic synthesis of complex oligosaccharides.. Chem Commun 50(54): 7132-7135. PMID:24854112

JL Praissman, DH Live, S. Wang, A. Ramiah, ZS Chinoy, GJ Boons, KW Moremen, L. Wells. 2014. B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of alpha-dystroglycan.. eLife Oct 3;3: doi:10.7554/-eLife.03943. PMID:25279697

H Hu, Y Huang, Y Mao, X Yu, Y Xu, J Liu, C Zong, GJ Boons, C Lin, Y Xia, J Zaia. 2014. A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra. Mol Cell Proteomics 13(9): 2490-2502. PMID:24925905

K. Talabnin, K. Aoki, P. Saichua, S. Wongkham, S. Kaewkes, G.J. Boons, B. Sripa, M. Tiemeyer. 2013. Stage-specific expression and antigenicity of glycorpotein glycans isolated from the human liver fluke, Opisthorchis viverrini. Int. J. Parasitol 43: 37-50. PMID:23174105

S. Kaeothip, G.J. Boons. 2013. Chemical synthesis of beta-arabinofuranosyl containing oligosaccharides derived from plant cell wall extensins. Org. Biomol. Chem. 11(31): 5136-5146. PMID:23817551

S. Arumugam, S.V. Orski, N.E. Mbua, C. McNitt, G.J. Boons, J. Locklin, V.V. Popik. 2013. Photo-click chemistry strategies for spatiotemporal control of metal-free ligation, labeling, and surface derivatization. Pure Appl. Chem. 85(7): 1499-1513.

C. Zong, A. Venot, O. Dhamale, G.J. Boons. 2013. Fluorous supported modular synthesis of heparin sulfate oligosaccharides. Org. Lett. 15: 342-345. PMID:23293947

J. Heimburg-Molinaro, J.W. Priest, D. Live, G.J. Boons, X. Song, R.D. Cummings, J.R. Mead. 2013. Microarray analysis of the human antibody response to synthetic. Int. J. Parasitol. 43: 901-907. PMID:23856596

N.E. Mbua, H.R. Flanagan-Steet, S. Johnson, M.A. Wolfert, G.J. Boons, R. Steet. 2013. Abnormal accumulation and recycling of glycoproteins visualized in Niemann-Pick type C cells using the chemical reporter strategy. Proc. Natl. Acad. Sci USA 110: 10207-10212. PMID:23733943

Z. Wang, Z. Chinoy, S. Ambre, W. Peng, R. McBride, R.P. de Vries, J. Glushka, J.C. Paulson, G.J. Boons. 2013. A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans. Science 341: 379-383. PMID:23888036

D. Live, L. Wells, G.J. Boons. 2013. Dissecting the molecular basis for the role of O-mannosylation pathway in disease: alpha-dystroglycan and forms of muscular dystrophy. ChemBioChem Dec 16; 14(18): 2392-2402. PMID:24318691

N.E. Mbua, X. Li, H.R. Flanagan-Steet, L. Meng, K. Aoki, K.W. Moremen, M.A. Wolfert, R. Steet, G.J. Boons. 2013. Selective exo-enzymatic labeling (SEEL) of N-glycans of living cells by recombinant ST6Gal. . Angewandte 52: 13012-13015. PMID:24129959

P.A. Ledin, N. Kolishetti, G.J. Boons. 2013. Multi-Functionalization of Polymers by Strain-Promoted Cycloadditions. Macromolecules 46(19): 7759-7768. PMID:24511157

M.A. Wolfert, G.J. Boons. 2013. Adaptive immune activation: glycosylation does matter. Nat Chem Biol 9(12): 776-784. PMID:24231619

H. Li, K. Mo, Q. Wang, C.K. Stover, A. DiGiandomenico, G.J. Boons. 2013. Epitope mapping of monoclonal antibodies using synthetic oligosaccharides uncovers novel aspects of immune recognition of the PsI exopolysaccharide of Pseudomonas aeruginosa. Chemistry 19(51): 17425-17431. PMID:24248772

V. Lakshminarayanan, P. Thompson, M.A. Wolfert, T. Buskas, J.M. Bradley, L.B. Pathangey, C.S. Madsen, P.A. Cohen, S.J. Gendler, G.J. Boons. 2012. Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine. Proc. Natl. Acad. Sci. U.S.A. 109: 261-266. PMID:22171012

W.A. van der Linden, N. Li, S. Hoogendoorn, M. Ruben, M. Verdoes, J. Guo, G.J. Boons, G.A. van der Marel, B.I. Florea, H.S. Overkleeft. 2012. Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study. Bioorg. Med. Chem. 15: 662-666. PMID:21757357

T.K. Nguyen, S. Arungundram, V.M. Tran, K. Raman, K. Al-Mafraji, A. Venot, G.J. Boons, B. Kuberan. 2012. A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action of D-glucosaminyl 3-O-sulfotransferase-3a. Mol. BioSyst. 8: 609-614. PMID:22116385

R. Lawrence, J.R. Brown, K. Al-Mafraji, W.C. Lamanna, J.R. Beitel, G.J. Boons, J.D. Esko, B.E. Crawford. 2012. Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nat. Chem. Biol. 8: 197-201. PMID:2231271

J. Guo, G. Chen, X. Ning, X. Li, J. Zhou, A. Jagielska, B. Xu, G.J. Boons. 2012. A chemo-mechanical tweezer for single molecular characterization of soft materials. Chem. Eur. J. 18(15): 4568-4574. PMID:22374886

F. Friscourt, P.A. Ledin, N.E. Mbua, H.R. Flanagan-Steet, M.A. Wolfert, R. Steet, G.-J. Boons. 2012. Polar dibenzocyclooctynes for selective labeling of extracellular glycoconjugates of living cells. J. Am. Chem. Soc. 134: 5381-5389. PMID:22376061

T. Fang, K.F. Mo, G.J. Boons. 2012. Stereoselective assembly of complex oligosaccharides using anomeric sulfonium ions as glycosyl donors. J. Am. Chem. Soc. 2: 7545-7552. PMID:22475263

T.J. Boltje, W.E. Zhong, J. Park, M.A. Wolfert, W. Chen, J.G. Boons. 2012. Chemical synthesis and immunological evaluation of the inner core oligosaccharide of Francisella tularensis. J. Am. Chem. Soc. 134: 14255-14262. PMID:22867268

K.F. Mo, X. Li, H. Li, L.Y. Low, C.P. Quinn, G.J. Boons. 2012. Endolysins of Bacillus anthracis bacteruiophages recognize unique carbohydrate epitopes of vegetative cell wall polysaccharides with high affinity and selectivity . J. Am. Chem. Soc. 134: 15556-15562 [19948]. PMID:22935003

F. Friscourt, C.J. Fahrni, G.J. Boons. 2012. A fluorogenic probe for the catalyst-free deterction of azide-tagged molecules. J. Am Chem. Soc. 134: 18809-18815. PMID:23095037

P.A. Ledin, F. Friscourt, J. Guo, G.J. Boons. 2011. Convergent assembly and surface modification of multifunctional dendrimers by three consecutive click reactions. Chem. Eur. J. 17: 839-846. PMID:21226098

T.J. Boltje, H.H. Kim, J. Park, G.J. Boons. 2011. Stereoelectronic effects determine oxacarbenium vs β-sulfonium ion mediated glycosylations. Org. Lett. 13: 284-287. PMID:21158475

B.C. Sanders, F. Friscourt, P.A. Ledin, N.E. Mbua, S. Arumugam, J. Guo, T.J. Boltje, V.V. Popik, G.J. Boons. 2011. Metal-free sequential [3+2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity. J. Am. Chem. Soc. 133: 949-957. PMID:21182329

H.B. Oh, F.E. Leach, S. Arungundram, K. Al-Mafraji, A. Venot, G.J. Boons, I.J. Amster. 2011. Multivariate analysis of electron detachment dissociation and infrared multiphoton dissociation mass spectra of heparan sulfate tetrasaccharides differing only in hexuronic acid stereochemistry. J. Am. Soc. Spectrom. 22: 582-590. PMID:21472576

H. van der Wei, J.M. Johnson, Y. Xu, C.V. Karunaratne, K.D. Wilson, Y. Vohra, G.J. Boons, C.M. Taylor, B. Bendiak, C.M. West. 2011. Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and α-N-acetylglucosaminyltransferase enzymes involved in O2-signaling in Dictyostelium. Biochemistry 50: 1700-1713. PMID:21247092

E.G. Saile, G.J. Boons, T. Buskas, R.W. Carlson, E.L. Kannenberg, J.R. Barr, A.E. Boyer, M. Gallegos-Candela, C.P. Quinn. 2011. Antibody responses to a spore carbohydrate antigen as a marker of non-fatal inhalation anthrax in rhesus macaques. Clin. Vaccine Immunol. 18: 743-748. PMID:21389148

D.R. Kashyap, M. Wang, L.H. Liu, G.J. Boons, D. Gupta, R. Dziarski. 2011. Peptidoglycan recognition proteins kill bacteria by inducing suicide through protein-sensing two-component systems. Nat. Med. 17: 676-683. PMID:21602801

M. Mir, J. Asong, X. Li, J. Cardot, G.J. Boons, R.N. Husson. 2011. The extracellular domain of the Mycobacterium tuberculoisis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization. PLoS Pathog. 7: e1002182-.

F.E. Leach III, J.J. Wolff, Z. Xiao, M. Ly, T.N. Laremore, S. Arungundram, K. Al-Mafraji, A. Venot, G.J. Boons, R.J. Linhardt, I.J. Amster. 2011. Negative electron transfer dissociation Fourier transform mass spctrometry of glycosaminoglycan carbohydrates. Eur. J. Mass Spectrom 17: 167-176. PMID:21719917

N.E. Mbua, J. Guo, M.A. Wolfert, R. Steet, G.J. Boons. 2011. Strain-promoted alkyne-azide cycloadditions (SPAAC) reveal new features of glycoconjugate biosynthesis. ChemBioChem 12: 1912-1921.

P. Zhao, R. Viner, C.F. Teo, G.J. Boons, D. Horn, L. Wells. 2011. Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment. J. Proteome Res. 10: 4088-4104.

K. Mo, T. Fang, S. Stainaker, P.S. Kirby, M. Liu, L. Wells, M. Pierce, D.H. Live, G.J. Boons. 2011. Synthetic, structural and biosynthetic studies of an unusual phosphoglycopeptide derived from α-dystroglycan. J. Am. Chem. Soc. 133: 14418-14430.

Y. Akimoto, Y. Miura, T. Toda, M.A. Wolfert, L. Wella, G.J. Boons, G.W. Hart, T. Endo, H. Kawakami. 2011. Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4.. Clin Proteomics 8: 15-. PMID:21933451

X. Li, J. Guo, J. Asong, M.A. Wolfert, G.-J. Boons. 2011. Multifunctional surface modification of gold-stablized nanoparticles by bioorthogonal reactions. J. Am. Chem. Soc. 133: 11147-11153. PMID:21678979

C.F. Teo, S. Ingale, G.A. Elsayed, M.A. Wolfert, L. Wells, G.J. Boons. 2010. Generation of O-GlcNAc specific monoclonal antibodies using a novel synthetic immunogen. Nature Chem. Biol. 6: 338-343. PMID:20305658

L.J. Berghaus, J.N. Moore, D.J. Hurley, M.L. Vandenplas, B.P. Fortes, M.A. Wolfert, G.J. Boons. 2010. Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2,3, and 4. Comp. Immunol. Microbiol. Infect. Dis. 33: 443-454. PMID:19732955

K.K. Maiti, M. DeCastro, A.M. Abbdel-Aal, M.I. Foote, M.A. Wolfert, G.J. Boons. 2010. Chemical synthesis and proinflammatory responses of monophosphoryol lipid A adjuvant candidates. Eur. J. Org. Chem. 1: 80-91. PMID:20228877

X. Ning, R.P. Temming, J. Dommerholt, J. Guo, D.B. Ania, M.F. Ebetes, M.A. Wolfert, G.J. Boons, F.L. Van. 2010. Protein modification by strain-promoted alkyne-nitrone cycloaddition. Angew. Chem. Int. Ed. Engl. 49: 3065-3068. PMID:20333639

T.J. Boltje, J.H. Kim, J. Park, G.J. Boons. 2010. Chiral-auxiliary mediated 1,2-cis glycosylations for the solid-supported synthesis of a biologfically important branched a-glucan. Nature Chem. Biol. 2: 552-557. PMID:20571573

T.J. Boltje, C. Li, G.J. Boons. 2010. A versatile set of orthogonal protecting groups for the preparation of highly branched oligosaccharides. Org. Lett. 12: 4636-4639. PMID:20845911

G.J. Boons. 2010. Liposomes modified by carbohydrate ligands can target B-cells for the treatment of B-cell lymphomas. Expert Rev. Vaccines 9: 1251-1256. PMID:21087105

F. Friscourt, G.J. Boons. 2010. One-pot three-step synthesis of 1,2,3-triazoles by copper-catalyzed cycloaddition of azxides with alkynes formed by a Sonogashira cross-coupling and desilylation. Org. Lett. 12: 4936-4939. PMID:20942390

J. Guo, G. Chen, X. Ning, M.A. Wolfert, X. Li, B. Xu, J.G. Boons. 2010. Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions. Chem. Eur. J. 16: 13360-13366. PMID:21077066

J. Gaekwad, Y. Zhang, W. Zhang, J. Reeves, M.A. Wolfert, G.J. Boons. 2010. Differential induction of innate immune responses by synthetic lipid A derivatives. J. Biol. Chem. 285: 29375-29386. PMID:20634284

J. Asong, M.A. Wolfert, K. Maiti, D. Miller, G.J. Boons. 2009. Binding and cellular activation studies reveal that toll-like receptor 2 can differentially recognize peptidoglycan from gram-positive and -negative bacteria. J. Biol. Chem. 284: 8643-8653. PMID:19164296

S. Ingale, M.A. Wolfert, T. Buskas, G.J. Boons. 2009. Increasing the antigenicity of synthetic tumor-associated carbohydrate antigens by targeting toll-like receptors. Chembiochem. 10: 455-463. PMID:19145607

G. Chen, X. Ning, B. Park, G.J. Boons, B. Xu. 2009. Simple, clickable protocol for atomic force microscopy tip midification and its application for trace ricin detection by recognition imaging. Langmuir 25: 2860-2864. PMID:19125690

D.A. Kuntz, W.E. Zhong, J. Guo, D.R. Rose, G.J. Boons. 2009. The molecular basis of inhibition of golgi mannosidase II by Mannostatin A. Chembiochem. 10: 268-277. PMID:19101978

C. Leoff, E. Saile, J. Rauvolfova, C.P. Quinn, A.R. Hoffmaster, W.E. Zhong, A.S. Mehta, G.-J. Boons, R.W. Carlson, E.L. Kannenberg. 2009. Secondary cell wall polysaccharides of Bacillus anthracis are antigens that contain specific epitopes which cross-react with three pathogenic Bacillus cereus strains that caused severe disease, and other epitopes common to all the Bacillus cereus stains tested. Glycobiology 19: 665-673. PMID:19270075

Y. Ferrand, E. Klein, N.P. Barwell, M.P. Crump, J. Jimenez-Barbero, C. Vincent, G.J. Boons, S. Ingale, A.P. Davis. 2009. A synthetic lectin for O-linked beta-N-acetylglucosamine (O-GlcNAc). Angew. Chem. Int. Ed. 48: 1775-1779. PMID:19072969

S. Arungundram, K. Al-Mafraji, J. Asong, F.E. Leach, I.J. Amster, A. Venot, J.E. Turnbull, G.J. Boons. 2009. Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies. J. Am. Chem. Soc. 131: 17394-173405. PMID:19904943

A.A. Poloukhtine, N.E. Mbua, M.A. Wolfert, G.J. Boons, VV Popik. 2009. Selective labeling of living cells by a photo-triggered click reaction. J. Am. Chem. Soc. 131: 15769-15776. PMID:19860481

T. Buskas, P. Thompson, G.J. Boons. 2009. Immunotherapy for cancer: synthetic carbohydrate-based vaccines. Chem. Commun. (Camb) 28: 5335-5349. PMID:19724783

Z.A. Wang, H. van der Wel, Y. Vohra, T. Buskas, G.J. Boons, C.M. West. 2009. Role of a cytoplasmic dual-function glycosyltransferase in O2 regulation of development in Dictyostelium. J. Biol. Chem. 284: 28896-288904. PMID:19687007

Y. Vohra, T. Buskas, G.J. Boons. 2009. Rapid assembly of oligosaccharides: A highly convergent strategy for the assembly of a glycosylated amino acid derived from PSGL-1. J. Org. Chem. 74: 6064-6071. PMID:19606831

N. Marina-Garcia, L. Franchi, Y.G. Kim, Y. Yu, D.E. Smith, G.J. Boons, G. Núñez. 2009. Clathrin-and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J. Immunol. 182: 4321-4327. PMID:19299732

T. Boltje, T. Buskas, G.J. Boons. 2009. Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research. Nature Chem. Biol. 1: 611-622. PMID:20161474

M. Vasan, J. Rauvolfava, M.A. Wolfert, C. Leoff, E.L. Kannenberg, C.P. Quinn, R.W. Carlson, G.-J. Boons. 2008. Chemical synthesis and immunological properties of oligosaccharides derived from the vegetative cell wall of Bacillus anthracis. Chembiochem. 9: 1716-1720. PMID:18563773

Y. Rao, T. Buskas, A. Albert, M.A. O'Neill, M.G. Hahn, G.-J. Boons. 2008. Synthesis and immunological properties of a tetrasaccharide portion of the B-side Chain of rhamnogalacturonan II (RG-II). Chembiochem. 9: 381-388. PMID:18196512

W.E. Zhong, D.A. Kuntz, B. Ember, H. Singh, K.W. Moremen, D.R. Rose, G.-J. Boons. 2008. Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J. Am. Chem. Soc. 130: 8975-8983. PMID:18558690

X. Ning, J. Guo, M.A. Wolfert, J.G. Boons. 2008. Visualizing metabolically-labeled glycoconjugates of living cells by copper-free and fast Huisgen cycloadditions. Angew. Chem. Int. Ed. 47: 2253-2255. PMID:18275058

Y. Zhang, J. Gaekwad, M.A. Wolfert, G.J. Boons. 2008. Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis. Chem. Eur. J. 14: 558-569. PMID:17943705

N. Marina-Garcia, L. Franchi, Y.G. Kim, D. Miller, C. McDonald, G.J. Boons, G. Nunez. 2008. Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces Caspase-1 activation via Cryopyrin/NLRP3 independently of Nod2. J. Immunol. 180: 4050-4057. PMID:18322214

J. Rauvolfova, A. Venot, G.J. Boons. 2008. Chemo-enzymatic synthesis of C-9 acetylated sialosides. Carbohydr. Res. 343: 1605-1611. PMID:18508039

Y. Vohra, M. Vasan, A. Venot, G.J. Boons. 2008. One-pot synthesis of oligosaccharides by combining reductive openings of benzylidene acetals and glycosylations. Org. Lett. 10: 3247-3250. PMID:18578494

Y. Zhang, J. Gaekwad, M.A. Wolfert, G.J. Boons. 2008. Synthetic tetra-acylated lipid as derived from Porphyromonas gingivalis are antagonists of human TLR4. Org. Biomol. Chem. 6: 3371-3381. PMID:18802645

J. park, T. Boltje, G.J. Boons. 2008. Direct and stereoselective synthesis of alpha-linked 2-deoxy-glycosides. Org. Lett. 10: 4367-4370. PMID:18763796

S. Liu, A. Venot, L. Meng, F. Tian, K.W. Moremen, G.J. Boons, J.H. Prestegard. 2007. Spin-labeled analogs of CMP-NeuAc as NMR probes of the alpha-2-6-sialyltransferase ST6Gal I. Curr. Opinion Chem. Biol. 14: 409-418. PMID:17462576

S. Ingale, M.A. Wolfert, J. Gaekwad, T. Buskas, G.J. Boons. 2007. Robust immune responses elicited by a fully synthetic three-component vaccine. Nature Chem. Biol. 3: 663-667. PMID:17767155

Y. Rao, G.J. Boons. 2007. A highly convergent chemical synthesis of conformational epitopes of Rhamnogalacturonan II. Angew Chem. Int. Ed. Engl. 46: 6148-6151. PMID:17615607

M. Vasan, M.A. Wolfert, G.J. Boons. 2007. Agonistic and antagonistic properties of a Rhizobium sin-1 lipid A modified by an ether-linked lipid. Org. Biomol. Chem. 5: 2087-2097. PMID:17581652

Y. Zhang, M.A. Wolfert, G.J. Boons. 2007. The influence of the long chain fatty acid on the antagonistic activities of Rhizobium sin-1 lipid A. Bioorg. Med. Chem. Lett. 15: 4800-4812. PMID:17513113

S. Cho, Q. Wang, C.P. Swaminathan, D. Hesek, M. Lee, G.J. Boons, S. Mobashery, R.A. Mariuzza. 2007. Structural insights into the bactericidal mechanism of human peptidogycan recognition proteins. Proc. Natl. Acad. Sci. USA 104: 8761-8766. PMID:17502600

J. Park, S. Kawatkar, J.H. Kim, G.J. Boons. 2007. Stereoselective glycosylations of 2-azido-2-eoxy-glucosides using intermediate sulfonium ions. Org. Lett. 9: 1959-1962. PMID:17432867

M.A. Wolfert, A. RoyChowdhury, G.J. Boons. 2007. Modifications of the structure of peptidoglycan is a strategy to avoid detection by NODI. Infect. Immun. 75: 706-713. PMID:17145940

Y. Zhang, J. Gaekwad, M.A. Wolfert, G.J. Boons. 2007. Modulation of innate immune responses with synthetic lipid A derivaties. J. Am. Chem. Soc. 129: 5200-5216. PMID:17391035

X. Li, S. Wang, J. Qi, S.F. Echtenkamp, R. Chatterjee, M. Wang, R. Dziarski, D. Gupta, G.J. Boons. 2007. Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections. Immunity 27: 518-529. PMID:17892854

T. Buskas, S. Ingale, G.J. Boons. 2006. Glycopeptides as versatile tools for glycobiology. Glycobiology 16: 113R-136R. PMID:16675547

C.P. Swaminathan, P.H. Brown, A. RoyChowdhury, Q. Wang, R. Guan, N. Silverman, W.E. Goldman, R.A. Mariuzza, G.J. Boons. 2006. Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc. Natl. Acad. Sci. USA 103: 684-689. PMID:16407132

H.S. Lee, M.A. Wolfert, Y. Zhang, G.J. Boons. 2006. The 2-aminogluconate isomer of Rhizobium sin-1lipid A can antagonize TNF-a production induced by enteric LPS. Chem. Bio. Chem. 7: 140-148. PMID:16317789

Y. Rao, A. Venot, E.E. Swayze, R.H. Griffey, G.J. Boons. 2006. Trisaccharide mimetics of the aminoglycoside antibiotic neomycin. Org. Biomol. Chem. 4: 1328-1337. PMID:16557321

R. Guan, P.H. Brown, C.P. Swaminathan, A. RoyChowdhury, G.J. Boons, R.A. Mariuzza. 2006. Crystal structure of human peptidoglycan recognition protein la bound to a muramyl pentapeptide from Gram-positive bacteria. Protein Sci. 15: 1199-1206. PMID:16641493

L. Buts, A. Garcia-Pino, A. Imberty, N. Amiot, G.J. Boons, S. Beeckmans, L. Versees, L. Wyns, R. Loris. 2006. Structural basis for the recognition of complex-type biatennary oligosaccharides by Pterocarpus angolensis lectin. FEBS J. 273: 2407-2420. PMID:16704415

S. Kawatkar, D.A. Kuntz, R.J. Woods, D.R. Rose, G.J. Boons. 2006. The structural basis of the inhibition of golgi a-mannosidase II by mannostatin A and the role of the thiomethyl moiety in protein ligand interactions. J. Am. Chem. Soc. 128: 8310-8319. PMID:16787095

J. Guo, J. Asong, G.J. Boons. 2006. Selective inhibition of glycosidases by feedback prodrugs. Angew. Chem. Int. Ed. 45: 5345-5348. PMID:16847860

J.H. Kim, H. Yang, V. Khot, D. Whitfield, G.J. Boons. 2006. Stereoselective glycosylations using (R)- or (S)-(ethoxycarbonyl)benzyl chiral auxilaries at C-2 of glycopyronsyl donors. Eur. J. Org. Chem. 22: 5007-5028.

M.S. Alphey, A. Burton, M.D. Urbaniak, G.J. Boons, M.A.J. Ferguson, W.N. Hunter. 2006. Tyrpanosoma brucei UDP-galactose-4`-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4fluoro-a-D-galactose. Acta. Crystallogr. Sec.F Struct. Biol. Cryst.Commun. 62: 829-834. PMID:16946458

X. Zhu, S. Kawatkar, Y. Rao, G.J. Boons. 2006. A practical approach for the stereoselective introduction of b-arabionofuranosides. J. Amer. Chem. Soc. 128: 11948-11957. PMID:16953636

S. Ingale, T. Buskas, G.J. Boons. 2006. Synthesis of glyco(lipo)peptides by liposome-mediated native chemical ligation. Org. Lett. 8: 5785-5788. PMID:17134272

A. Mehta, E. Saile, W. Zhong, T. Buskas, R. Carlson, E. Kannenberg, Y. Reed, C.P. Quinn, G.J. Boons. 2006. Synthesis and antigenic analysis of the Bc1A glycoprotein oligosaccharide from Bacillus anthracisexosporium. Chem. Eur. J. 12: 9136-9149. PMID:17133642

J.H. Kim, H. Yang, G.-J. Boons. 2005. Stereoselective glycosylations reactions with chiral auxiliaries. Angew. Chem. Int. Ed. 44: 947-949. PMID:15630711

A. Siriwardena, H. Strachan, S. El-Daher, G. Way, B. Winchester, J. Glushka, K. Moremen, G.J. Boons. 2005. Potent and selective inhibition of Class II a-D-mannosidase activity by a bicyclic sulfonium salt. Chembiochem. 6: 845-848.

D. Majumdar, G.A. Elsayed, T. Buskas, G.J. Boons. 2005. Synthesis of proteophosphoglycans of Leishmania major and Leishmania mexicana. J. Org. Chem. 70: 1691-1697. PMID:15730289

R. Guan, A. RoyChowdhury, B. Ember, V.S. Kumar, G.J. Boons, R.A. Mariuzza. 2005. Crystal structure of a peptidoglycan recognition protein (PGRP) in complex with a muramyl tripeptide from Gram-positive bacteria. J. Endotoxin Res. 11: 41-46. PMID:15826377

D. Cato, T. Buskas, G.J. Boons. 2005. Highly efficient stereospecific preparation of Tn and TF building blocks using thioglycosyl donors and the Ph2SO/Tf2O promoter system. J. Carbohydr. Chem. 24: 503-516.

J.H. Kim, H. Yang, J. Park, G.J. Boons. 2005. A general strategy for stereooselective glycosylations. J. Am. Chem. Soc. 127: 12090-12097. PMID:16117550

T. Buskas, S. Ingale, G.J. Boons. 2005. Towards a fully synthetic carbohydrate-based anticancer vaccine: synthesis and immunological evaluation of the lipidated glycopeptide containing the tumor-associated tn-antigen. Angew. Chem. Int. Ed. 44: 5985-5988. PMID:16108081

T. Buskas, Y. Li, G.J. Boons. 2005. Synthesis of a dimeric Lewis antigen and the evaluation of the epitope specificity of antibodies elicited in mice. Chem. Eur. J. 11: 5457-5467. PMID:16013028

A. RoyChowdhury, M.A. Wolfert, G.J. Boons. 2005. Synthesis and pro-inflammatory properties of muramyl tripeptides containing lysine and diaminopimelic acid moieties. Chembiochem. 6: 2088-2097. PMID:16222728

V.S. Kumar, A. RoyChowdhury, B. Ember, Q. Wang, R. Guan, R.A. Mariuzza, G.J. Boons. 2005. Selective recognition of synthetic lysine and meso diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition proteins I - alpha and S. J. Biol. Chem. 280: 37005-37012. PMID:16129677

A. Roychowdhury, G.J. Boons. 2005. The synthesis of diaminopimelic acid containing peptidoglycan fragments using metathesis cross couplings. Tetrahedron Lett. 46: 1675-1678.

R. Guan, A. RoyChowdhury, B. Ember, V.S. Kumar, G.-J. Boons, R.A. Mariuzza. 2004. Structural basis for peptidoglycan binding by peptidoglycan recognition proteins. Proc. Natl. Acad. Sci. USA 101: 17168-17173. PMID:15572450

A. Venot, E.E. Swayze, R.H. Griffey, G.-J. Boons. 2004. Disaccharide mimetics of the aminoglycoside antibiotic neamine. Chem. Bio. Chem. 5: 1228-1236. PMID:15368574

B. Santhanam, M.A. Wolfert, J.N. Moore, G.-J. Boons. 2004. Synthesis and biological evaluation of a lipid-A derivative that contains an aminogluconate moiety. Chem. Eur. J. 10: 4798-4807. PMID:15372693

B. Santhanam, G.-J. Boons. 2004. Preparation of a lipid A derivative that contains a 27-hydroxyoctacosanoic acid moiety. Org. Lett. 6: 3333-3336.

T. Buskas, Y. Li, G.-J. Boons. 2004. The immunogenicity of the tumor-associated antigen may be suppressed by a bifunctional cross-linker required for coupling to a carrier protein. Chem. Eur. J. 10: 3517-3524. PMID:15252797

P. Narendran, K. Elsegood, N.J. Leech, W.M. Macindoe, G.-J. Boons, C.M. Dayan. 2004. Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes. Immunology 111: 422-429. PMID:15056379

M.C. Galan, A. Venot, G.-J. Boons. 2004. The design and synthesis of a selective inhibitor of fucosyltransferase VI. Org. & Biomol. Chem. 2: 1376-1380. PMID:15105929

M.C. Galan, C. Dodson, A. Venot, G.-J. Boons. 2004. Glycosyltransferase activity can be selectively modulated by chemical modifications of acceptor substrates. Biorg. Med. Chem. Lett. 14: 2205-2208. PMID:15081009

G. Watt, G.-J. Boons. 2004. A convergent strategy for the preparation of N-glycan core di-, tri-, and pentasaccharide thioaldoses for the site-specific glycosylation of peptides and proteins bearing free cysteines. Carbohydr. Res. 339: 181-193. PMID:14698875

B. Li, S.P. Kawatkar, G.S. Strachan, H. Strachan, R.J. Woods, A. Siriwardena, K.W. Moremen, G.J. Boons. 2004. Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Chem. BioChem. 5: 1220-1227. PMID:15368573

A. Demchenko, M.A. Wolfert, B. Santhanam, J.N. Moore, G.J. Boons. 2003. Synthesis and biological evaluation of Rhizobium sin-1 Lipid A derivatives. J. Am. Chem. Soc. 125 (20): 6103-6112. PMID:12785841

G.A. Elsayed, G.J. Boons. 2003. Chemical synthesis of a-D-mannosylphosphate serine derivatives: A new class of synthetic glycopeptides. Synlett 9: 1373-1375.

G. Pinhal-Enfiled, M Ramanathan, G. Hasko, S.N. Vogel, A.L. Salzman, G.J. Boons, S.J. Leibovich. 2003. An angiogenic switch in macrophages involving synergy between toll-like receptors 2,4,7, and 9, and adenosine A24 receptors. Am. J. of Path. 163 (2): 711-721. PMID:12875990

S. Thobhani, B. Ember, A. Siriwardena, G.J. Boons. 2003. Multivalency and the mode of action of bacterial sialidases. J. Am. Chem. Soc. 125 (24): 7154-7155. PMID:12797770

G. Watt, J. Lund, M. Levens, V.S.K. Kolli, R. Jefferis, G.J. Boons. 2003. Site-epecific glycosylation of an aglycosylated human lgG1-Fc antobody protein generates neoglycoproteinswith enhanced function. Chem. and Biol. 10: 807-814. PMID:14522051

M.C. Galan, A.P. Venot, G.J. Boons. 2003. Glycosyltransferase activity can be modulated by small conformational changes of acceptor substrates. Biochemistry 42: 8522-8529. PMID:12859199

D. Majumder, T. Zhu, G.J. Boons. 2003. Synthesis of oligosaccharides on soluble high- molecular-weight branched polymers in combination with purification by nanofiltration. Org. Lett. 5: 3591-3594. PMID:14507180

A Prabhu, A Venot, GJ Boons. 2003. A new set of orthogonal protecting froups for the modular synthesis of heparan sulfate fragments. Org. Lett. 5: 4975-4978. PMID:14682743

M.C. Galan, A.P. Venot, J. Glushka, A. Imberty, G.-J. Boons. 2003. Chemo-enzymatic synthesis of conformationally constrained oligosaccharides. Org. & Biomol. Chem. 1: 3891-3899. PMID:14664380

E. Arranz-Plaza, A.S. Tracy, A. Siriwardena, J.M. Pierce, G.J. Boons. 2002. High avidity, low affinity multivalent interactions and the block of polspermy in Xenopus laevis. J. Am. Chem. Soc. 124: 13035-13046. PMID:12405830

A. Chowdhury, A. Siriwardena, G.J. Boons. 2002. A highly covergent approach for the synthesis of disaccharide repeating units of peptidoglycan. Tetrahedron Lett. : 7805-7807.

C. DeMeo, A. Demchenko, G.J. Boons. 2002. Trifluroacetamido substituted sialyl donors for the preparation of sialyl galactosides. Aus. J. Chem. 55: 131-134.

G.A. Elsayed, T. Zhu, G.J. Boons. 2002. Demixing libraries of saccharides using a multi-linker approach in combination with a soluble polymeric support. Tetrahedron Lett. 43(26): 4691-4694.

M.C. Galan, A.P. Venot, J. Glushka, A. Imberty, G.J. Boons. 2002. a-(2,6)-Sialytransferase catalyzed sialylations of conformationally constrained oligosaccharides. J. Am. Chem. Soc. 124: 5964-5973. PMID:12022829

R. Geurtsen, G.J. Boons. 2002. Chemoselective glycosylations of sterically hindered glycosyl acceptors. Tetrahedron Lett. 43: 9429-9431.

R. Geurtsen, G.J. Boons. 2002. Regioselective glycosylations in solution and on soluble and insoluble polymeric support. Eur. J. Org. Chem. : 1473-1477.

M.A. Wolfert, T.F. Murray, G.J. Boons, J.N. Moore. 2002. The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan. J. Biol. Chem. 42: 39179-39186. PMID:12151399

M.F. Haller, G.J. Boons. 2002. Selectively projected disaccharide building blocks for modular synthesis of heparin fragments (Part 2). Eur. J. Org. Chem 13: 2033-2038.

M. Haller, G.J. Boons. 2001. Toward a modular approach for heparin synthesis. Perkin Trans. I 8: 814-822.

A. Demchenko, G.J. Boons. 2001. A highly convergent synthesis of a complex oligosaccharide derived from group B type III Streptococcus. J. Org. Chem. 66: 2547-2554. PMID:11304169

T. Zhu, G.J. Boons. 2001. A highly efficient synthetic strategy for polymeric support synthesis of Lex, Ley, and H-type 2 oligosaccharides. Chem. Eur. J. 7: 2382-2389. PMID:11446640

M. McWatt, G.J. Boons. 2001. Parallel combinatorial synthesis of dendrimers and their hydrogelation properties. Eur. J. Org. Chem. 13: 2535-2545.

A. Siriwardena, M. Jorgensen, M.A. Wolfert, N.L. Vandenplas, J.N. Moore, G.J. Boons. 2001. Synthesis and proinflammatory effects of peptidoglycan-derived neoglycopeptide polymers. J. Am. Chem. Soc. 123: 8145-8146. PMID:11506583

C. Clarke, R.J. Woods, A. Cooper, M.A. Nutley, G.-J. Boons. 2001. The involvement of water in carbohydrate-protein binding. J. Am. Chem. Soc. 123: 12238-12247. PMID:11734024

T. Zhu, G.J. Boons. 2001. Thioglycosides protected as trans-2,3-cyclic carbonates in chemoselective glycosylations. Org. Lett. 3: 4201-4203. PMID:11784177

D.B. Kearns, A. Venot, P.J. Bonner, B.J.H. Stevens, G.J. Boons, L.J. Shimkets. 2001. Identification of a developmental chemoattractant in Myxococcus xanthus through metabolic engineering. Proc. Natl. Acad. Sci. USA 98: 13990-13994. PMID:11717456

E. Arranz, G.J. Boons. 2001. The 2-(allyloxy)phenyl acetyl ester as a new relay protecting group for oligosaccharide synthesis. Tetrahedron Lett. 42: 6469-6471.

C. De Meo, A.V. Demchenko, G.J. Boons. 2001. A stereoselective approach for the synthesis of a-sialosides. J. Org. Chem. 66: 5490-5497. PMID:11485473

F. Reichel, A.M. Roelofsen, H.P.M. Geurts, S.J. van der Gaast, M.C. Feitera, G.J. Boons. 2000. Synthesis and supramolecular characterization of a novel class of glycopyranosyl containing amphiphiles that form tubular structures. J. Org. Chem. 65: 3357-3366. PMID:10843617

T. Zhu, G.-J. Boons. 2000. A new set of orthogonal protecting groups for oligosaccharide synthesis on a polymeric support. Tetrahedron Asym. 11: 199-205.

Y. Bai, G.-J. Boons, A. Burton, M. Johnson, M. Haller. 2000. Vinyl glycosides in oligosaccharide synthesis. (Part 6): 3-buten-2-yl 2 azido-2-deoxy glycosides and 3-buten-2-yl-phthalimido-2-deoxy glycosides as novel glycosyl donors. J. Carbohydr. Chem. 19: 939-958.

G. Belogi, T. Zhu, G.J. Boons. 2000. Polystyrylboronic acid as a re-useable polymeric support for oligosaccharide synthesis. Tetrahedron Lett. 41: 6965-6968.

G. Belogi, T. Zhu, G.J. Boons. 2000. Polymer supported oligosaccharide synthesis by a loading-release-reloading strategy. Tetrahedron Lett. 41: 6969-6972.

T. Zhu, G.J. Boons. 2000. A novel and efficient synthesis of a dimeric Lex oligosaccharide on polymeric support. J. Am. Chem. Soc. 41: 10222-10223.

G.J. Boons, A. Demchenko. 2000. Recent advances in O-sialylation. Chem. Rev. 100: 4539-4565.

T. Zhu, G.J. Boons. 2000. Intermolecular aglycon transfer of ethyl thioglycosides can be prevented by judicious choice of protecting groups. Carbohydr. Res. 329: 709-715. PMID:11125813

A.V. Demchenko, G.-J. Boons. 1999. A novel direct glycosylation approach for the synthesis of dimers of N-acetylneuraminic acid. Eur. J. Chem. 5: 1278-1283.

A.V. Demchenko, E. Rousson, G.-J. Boons. 1999. Stereoselective 1,2-cis-galactosylation assisted by remote neighboring group participation and solvent effects. Tetrahedron Lett. 40: 6523-6526.

N. Navarre, N. Amiot, A. van Oijen, A. Imberty, A. Poveda, J. Jimenez-Barbero, A. Cooper, M.A. Nutley, G.-J. Boons. 1999. Synthesis and conformational analysis of a conformationally constrained trisaccharide, and complexation properties with concanavalin A. Eur. J. Chem. 5: 2281-2294.

G.-J. Boons. 1999. Combinatorial approaches in oligosaccharide synthesis. Carbohydrates in Europe 27: 28-32.

R. Geurtsen, F. Cote, M.G. Hahn, G.-J. Boons. 1999. A novel chemoselective glycosylation strategy for the rapid convergent assembly of phytoalexin-elicitor active oligosaccharides and their photo-reactive derivatives. J. Org. Chem. 64: 7828-7835.

F. Reichel, A.M. Roelofsen, H.P.M. Geurts, T.I. Hamalainen, M.C. Feiters, G.-J Boons. 1999. Stereochemical dependence of the self-assembly of the immunoadjuvants Pam3Cys and Pam3Cys-Ser. J. Am. Chem. Soc. 121: 7989-7997.

T. Zhu, G.-J. Boons. 1999. A two directional and highly convergent approach for the synthesis of the tumor-associated antigen globo-H. Agnew. Chem. Int. Ed. 38: 3495-3497. PMID:10602219

S.G. Bowers, D.M. Coe, G.-J. Boons. 1998. Application of the 2,5-dimethylpyrrole group as a new and orthogonal amine-protecting group in oligosaccharide synthesis. J. Org. Chem. 63: 4570-4571.

A. Demchenko, G.-J. Boons. 1998. A novel and versatile glycosyl donor for the preparation of glycosides of N-acetylneuraminic acid. Tetrahedron Lett. 39: 3065-3068.

M. Johnson, C. Arles, G.-J. Boons. 1998. Vinyl glycosides in oligsoaccharide synthesis (part 5): a latent-active glycosylation strategy for the preparation of branched trisaccharide libraries. Tetrahedron Lett. 39: 9801-9804.

W. Mackindoe, A.H. van Oijen, G.-J. Boons. 1998. A unique and highly facile method for synthesizing disulfide linked neoglycoconjugates: a new approach for remodeling of peptides and proteins. Chem. Commun. 1998: 847-848.

F. Reichel, G.-J. Boons. 1998. Sweet promise. Chem. in Britain 34: 43-46.

T. Zhu, G.-J. Boons. 1998. Two-directional, convergent synthesis of a pentasaccharide that is involved in the hyperacute rejection response in xenotransplantation from pig to man. J. Chem. Soc. Perkin Trans. I. 1998: 857-861.

T. Zhu, G.-J. Boons. 1998. A two directional approach for the solid-phase synthesis of trisaccharide libraries. Angew. Chem. Int. Ed. 37: 1898-1900.

T. Zhu, G.-J. Boons. 1998. A two directional glycosylation strategy for the convergent assembly of oligosaccharides. Tetrahedron Lett. 39: 2187-2190.

Book Chapters

TJ Boltje, L Liu, GJ Boons. 2016. Controlling anomeric selectivity, reactivity, and regioselectivity in glycosylations using protecting groups. In: Glycocheical Syntehsis: Strategies and Applications (S-C Huang and MML Zulueta, eds, Vol.Chapter 4. Wiley, Inc.

CM West, H van der Wel, Z Chinoy, GJ Boons, TJ Gauthier, CM Taylor, Y Xu. 2015. Generating isoform-specific antibodies: Lessons from nucleocytoplasmic glycoprotein Skp1. In: Glycoscience: Biology and Medicine (N. Taniguchi, T. End, G.W. Hart, P.H. Seeberger, C.-H. Wong, eds.), Vol.927:934. Springer, Japan.

T.J. Boltje, R. Benedict, G.J. Boons. 2014. Highly stereoselective 1,2-cis-glycosylations employing the C-2 (S)-(phenylthiomethyl)benzyl ether as a chiral auxiliary. In: Carbohydrate Chemistry:Proven Synthetic Methods, Vol.2:3-8. CRC Press, Taylor and Francis Group.

F. Friscourt, G.J. Boons. 2013. Bioorthogonal reactions for labeling glycoconjugates. In: In: Click Chemistry in Glycoscience: New Developments and Strategies (Z.J. Witczak and R. Bielski, eds.), pp. 211-233. John Wiley & Sons, Inc.

G.J. Boons. 2010. Bioorthogonal chemical reporter methodology for visualization, isolation and analysis of glycoconjugates. In: Carbohydrate Chemistry: Chemical and Biological Approaches (A. Pilar Rauter and T.K. Lindhorst, eds.), Vol.36:152-167. RSC Publishing.

T. Buskas, P. Thompson, G.J. Boons. 2009. Semisynthetic and fully synthetic carbohydrate-based cancer vaccines. In: Carbohydrate-based vaccines and immunotherapies (Z. Guo and G.J. Boons, eds), pp. 263-311. John Wiley & Sons, Inc..

W.E. Zhong, G.J. Boons. 2008. Thioglycosides in oligosaccharide synthesis. In: Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance (A. Demchenko, ed.), pp. 261-302. Wiley-VCH.

C. De Meo, G.J. Boons, A.V. Demchenko. 2007. Synthesis of glycosides of sialic acid. In: Comprehensive Glycoscience, Volume 1 (J.P. Kamerling, ed., and G.J. Boons, Y.C. Lee, A. Suzuki, N. Taniguchi and A.G.J. Voragen, co-eds.), pp. 583-604. Elsevier B.V. Amsterdam, The Netherlands.

J.H. Kim, H. Yang, G.J. Boons. 2007. Stereoselective glycosylations using chiral auxiliaries. In: Frontiers in Modern Carbohydrate Chemistry (A. Demchenko, ed.), pp. 73-90. American Chemical Society, Washington, D.C..

G.J. Boons. 2003. Sialic acid chemistry and biochemistry. In: Carbohydrate-Based Drug Discovery (C.H. Wong, ed.), pp. 55-102. Wiley-VCH.

G.J. Boons, B. Santhanam. 2003. Phathalic anhydride. In: Encyclopedia of Reagents for Organic Synthesis, pp. 55-102. John Wiley & Sons, Inc. Press.

G.-J. Boons, T. Zhu. 2001. Two-direction glycosylations for the preparation of libraries of oligosaccharides. In: Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries (P. Seeberger, ed.), pp. 201-211. John Wiley & Sons, Inc. Press.

G.J. Boons. 2001. Glycosides as donors. In: Glycoscience I-III. 2001. (B. Fraser-Reid, J. Tatsuta and J. Thiem Eds.), Vol.1:551-581. Springer-Verlag, Berlin Heidelberg.

G.-J. Boons, K.J. Hale. 2000. Organic Synthesis with Carbohydrates. In: Sheffield Academic Press Ltd. England (Postgradute Chemistry Series) .

To Top