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Kelley Moremen
Distinguished Research Professor of Biochemistry and Molecular Biology


E-mail: moremen@uga.edu
Telephone: 706-542-1705
Fax: 706-542-4412

Short Biography
Research Interests
Publications
Lab-personal web site

Short Biography:
Dr. Moremen received his B.S. in Biology and Chemistry (1978) from Dickinson College and his Ph.D. in Molecular Biology (1984) from Vanderbilt University. Prior to joining the faculty at the CCRC in 1991, and spent five years as a Postdoctoral Fellow at Massachusetts Institute of Technology. Dr. Moremen has served as chair of the Glycobiology Gordon Research Conference, President, Board of Directors, and Secretary of the Society for Glycobiology. He directs efforts on an NIH funded multi-investigator 'Resource for Integrated Glycotechnology', a senior investigator on the NIH-funded 'National Center for Biomedical Glycomics', and is a lead Principal Investigator or Senior Investigator on eight additional grants from the NIH and Department of Energy. In 2018 he launched a biotech startup, Glyco Expression Technologies, Inc., as a part of the UGA Innovation Gateway. He has served on editorial boards of Journal of Biological Chemistry, Glycobiology, and Glycoconjugate Journal, numerous NIH grant review panels, and Scientific Advisory Boards of four biotech companies. In 2014 Dr. Moremen was appointed the Distinguished Research Professorship in Biochemistry and Molecular Biology at the University of Georgia. Dr. Moremen has 10 patents and over 150 publications.

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Research Interests:
Research in the Moremen lab focuses on the biochemistry, structure, and regulation of enzymes involved in the biosynthesis, recognition, and catabolism of mammalian glycoproteins. Carbohydrate structures on glycoproteins contribute to many biological recognition events during development, oncogenic transformation, and cell adhesion. Large numbers of intracellular and extracellular proteins contain covalently bound glycans and alterations in the synthesis and degradation of these structures can occur in human genetic diseases and cancer. Many questions remain regarding the regulation of glycosylation pathways, the structures and functions of the processing enzymes, and the specificity and regulation of protein-carbohydrate interactions during development. Research in the Moremen lab is focused on developing novel strategies to address contemporary problems in the regulation, roles, mechanism, and machinery of mammalian protein glycosylation with efforts in four main areas:

1) Structures, specificities and mechanisms of mammalian glycosylation enzymes: Studies on the mammalian glycosylation enzymes in the Moremen lab have expanded in recent years with the development of a unified design and expression platform (Repository of Glycan-related Expression Constructs) for recombinant production of all mammalian glycosyltransferases, glycosidases, and sulfotransferases (target gene list of >400 coding regions) in bacteria, baculovirus, and mammalian cells. This multi-investigator effort, initiated and coordinated within the Moremen lab, is focused on production of these recombinant enzymes and has led to new enzyme structures and insights into the structural basis for enzymatic glycan synthesis. This project has led to numerous additional applications in chemoenzymatic synthesis, biochemical and structural studies, and development of technologies for enzymatic modification of glycoproteins and glycolipids in cellular environments to monitor molecule redistribution in the course of disease. The goals of these studies are to provide a biochemical and structural understanding of glycan biosynthesis and catabolism as well as providing enzymatic catalysts for chemoenzymatic synthesis. This project has been funded by an NIH P01 grant (P01GM107012, Mammalian Glycosyltransferases for Use in Chemistry and Biology) and presently by a multi-investigator NIH R01 grant (R01GM130915, Origin of N-Glycan Site-Specific Heterogeneity). For further information please see: glycoenzymes.ccrc.uga.edu.

2) Protein-carbohydrate interactions: Cell-surface and extracellular glycoproteins and glycolipids play unique and critical roles in mammalian physiology. One of the major glycan classes at the cell surface and within the extracellular matrix are the proteoglycans (PGs) that play diverse roles as co-receptors for cell surface signaling, scaffolds for cell-matrix interactions, ligands that create morphogen or chemokine gradients in development and inflammation, and numerous other contributions to signaling and cell surface structure. Little is known about the details of PG interactions with binding partners or their mechanisms of biological function. The Moremen lab directs a multi-investigator project with goals to develop a novel, integrated technologies that will address the challenges of PG structures, interactions, and biological functions by leveraging advances in analytical, synthetic, structural, biochemical and biological tools. This project is funded by an NIH P41 grant (P41GM103390, Resource for Integrated Glycotechnology). For further information please see: glycotech.uga.edu.

3) Regulation of glycosylation machinery in mammalian systems: The Moremen lab is also involved in a collaborative project focused on determining the structures and regulation of glycans associated with glycoproteins and glycolipids in animal systems. The overall aims of the program are to examine the changes glycan structures during development with a particular focus on embryonic stem cell differentiation. The Moremen lab has developed platforms for analysis of glyco-gene transcript abundance using a custom real-time RT-PCR strategy as well as next-generation RNA-Seq methods. Integration of the transcript abundance data with the glycan structure analysis developed by other research groups in the CCRC will be accomplished through the bioinformatics group associated with the research program. This project is funded by an NIH P41 grant (P41GM103490, National Center for Biomedical Glycomics). For further information please see: glycomics.uga.edu

4) Structure and biochemistry of glycan trimming enzymes involved in glycoprotein biosynthesis and catabolism: The fourth area of focus in the Moremen lab is on the enzymes involved in glycan trimming in the secretory pathway that are essential for N-glycan maturation as well as playing a role in the catabolism of misfolded nascent glycoproteins in the endoplasmic reticulum (ER-associated degradation).

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Publications: Author's Last Name: Moremen

Journal Articles
Book Chapters are listed at the bottom of this page.

L.H. Liu, AR Prudden, CJ Capicciotti, GP Bosman, Yang JY, DG Chapla, KW Moremen, GJ Boons. 2019. Streamlining the chemoenzymatic synthesis of complex N-glycans by a stop and go strategy. Nat. Chem. 11: 161-169. PMID:30532014

M Nasirikenari, P Punch, A Lugade, S Neelamegham, Z Gao, KW Moremen, PN Bogner, Y Thanavala, JTY Lau. 2019. Acute lung inflammation is mitigated by systemic infusion of a recombinant sialyltransferase . Front Immunol 10: 48-. PMID:30778346

ZS Chinoy, C Bodineau, C Favre, KW Moremen, RV Duran, F Friscourt. 2019. Selective Engineering of Linkage Specific alpha-2,6-N-Linked Sialoproteins using Sydnone-Modified Sialic Acid Bioorthogonal Reporters . Angew Chem Int Ed Engl In press.

T Li, L Liu, N Wei, J-Y Yang, DG Chapla, KW Moremen, GJ Boons. 2019. An automation platform for the enzyme-mediated assembly of complex oligosaccharides. Nature Chem 11: 229-236. PMID:30792508

J Li, M Chen, Z Liu, L Zhang, BH Felding, KW Moremen, G Lauvau, M Abadier, K Ley, P Wu. 2019. A Single-step Chemoenzymatic Reaction for the Construction of Antibody-cell Conjugates ACS Central Science . ACS Central Science 4: 1633-1641. PMID:30648147

t Hart, T Li, MA Wolfert, S Wang, KW Moremen, GJ Boons. 2019. Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide . Org Biomol Chem In press.

M.R. Kudelka, A.V. Nairn, M.Y. Sardar, X. Sun, E.L. Chaikof, T. Ju, K.W. Moremen, R.D. Cummings. 2018. Isotopic labeling with cellular O-glycome reporter/amplification (ICORA) for comparative O-glycomics of cultured cells. Glycobiology 28(4): 214-222. PMID:29390058

K.W. Moremen, A. Ramiah, M. Stuart, J. Steel, L. Meng, F. Forouhar, H.A. Moniz, G. Gahlay, Z. Gao, D. Chapla, S. Wang, J.Y. Yang, P.K. Prabhakar, R. Johnson, M.D. Rosa, C. Geisler, A.V. Nairn, J. Seetharaman, S.C. Wu, L. Tong, H.J. Gilbert, J. LaBaer, D.L. Jarvis. 2018. Expression system for structural and functional studies of human glycosylation enzymes. Nature Chem. Biol. 14(2): 156-162. PMID:29251719

CT Saeui, AV Nairn, M Galizzi, C Douville, P Gowda, M Park, V Dharma, S Shah, A Clark, M Austin, KW Moremen, KJ Yarema. 2018. Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes. PLoS One 13(5): e0195812-. PMID:29847599

R Kadirvelraj, J-Y Yang, JH Sanders, L Liu, A Ramiah, PK Prabhakar, G-J Boons, ZA Wood, KW Moremen. 2018. Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. Proc Natl Acad Sci USA 115: 4637-4642. PMID:29666272

Q Gao, JY Yang, KW Moremen, JG Flanagan, JH Prestegard. 2018. Structural Characterization of a Heparan Sulfate Pentamer Interacting with LAR-lg1-2. Biochemistry 57: 2189-2199. PMID:29570275

A Lopez Aguilar, L Meng, X Hou, W Li, KW Moremen, P Wu. 2018. Sialyltransferase-based Chemoenzymatic Histology for the Detection of N- and O-glycans. Bioconjugate Chem 29: 1231-1239. PMID:29569918

JK Jensen, M Busse-Wicher, CP Poulsen, JU Fangel, PJ Smith, JY Yang, M-J Pena, MH Dinesen, HJ Martens, M Melkonian, GK Wong, KW Moremen, CG Wilkerson, HV Scheller, P Dupree, P Ulvskov, BR Urbanowicz, J Harholt. 2018. Identification of an algal xylan synthase KfXYS1 proves that there is functional orthology between algal and plant cell wall biosynthesis. New Phytologist 218: 1049-1060. PMID:29460505

JG Briard, H Jiang, KW Moremen, MS Macauley, P Wu. 2018. Cell-Based Glycan Arrays for Probing Glycan-Glycan Binding Protein Interactions. Nature Commun 9: 880-. PMID:29491407

Y Zhao, JY Yang, DF Thieker, Y. Xu, C. Zong, G-J Boons, Z.-J. Liu, RJ Woods, KW Moremen, IJ Amster. 2018. A traveling wave ion mobility spectrometry (TWIMS) study of the Robo 1-heparan sulfate interaction. J Am Soc Mass Spectrom 29(6): 1153-1165. PMID:29520710

SH Rouhanifard, AL Aguilar, L Meng, K Izumori, KW Moremen, P Wu. 2018. Engineered glycocalyx regulates stem cell proliferation in crypt organoids. Cell Chem Biol 25: 1-8. PMID:29429899

M Kudelka, AV Nairn, MY Sardar, X. Sun, EL Chaikof, KW Moremen, RD Cummings. 2018. Isotopic Labeling with Cellular O-glycome Reporter/Amplification (ICORA) for Comparative O-glycomics of Cultured Cells. Glycobiology 28: 214-222. PMID:29390058

H Jiang, A Lopez-Aguilar, L Meng, Z Gao, Y Liu, X Tian, G Yu, B Ovryn, KW Moremen, P Wu. 2018. Modulating Cell-Surface Receptor Signaling and Ion Channel Functions by In Situ Glycan Editing. Angew Chem Int Ed 57: 967-971. PMID:29292859

A Epp, J Hobusch, Y Bartsch, S Eschweiler, C Mobs, A Hall, SC Morris, D Petzold, G-M Lilenthal, C Engellenner, J Bitterling, J Petry, R Rahmoller, M Collin, KW Moremen, RT Strait, V Blanchard, A Petersen, T Gemoll, JK Habermann, F Petersen, A Nandy, H Kahlert, M Hertl, W Pfutzner, U Jappe, FD Finkelman, M Ehlers. 2018. Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J Allergy Clin Immunol 141: 399-402. PMID:28728998

MJ Moure , A Eletsky, Q Gao, LC Morris, JY Yang, D Chapla, Y Zhao, C Zong, IJ Amster, KW Moremen, GJ Boons, JH Prestegard. 2018. Paramagnetic tag for glycosylation sites in glycoproteins: Structural constraints on heparan sulfate binding. ACS Chem. Biol. 13(9): 2560-2567. PMID:30063822

RA Amos, S. Pattathil, JY Yang, MA Atmodjo, BR Urbanowicz, KW Moremen, D. Mohnen. 2018. A two-phase model for the non-processive biosynthesis of homoglacturonan polysaccharides by the GAUT1:GAUT7 complex. J. Biol. Chem. 293: 19047-19063. PMID:30327429

W Muchero, KL Sondreli, JG Chen, BR Urbanowicz, J Zhang, V Singan, Y Yang, RS Brueggerman, J Franco-Coronado, N Abraham, JY Yang, KW Moremen, AJ Weisberg, JH Chang, E Lindquist, K Berry, P Ranjan, SR Jawdy, J Schmutz, GA Tuskan, JM LeBoldus. 2018. Association mapping, transcriptomics, and transient expression identify candidate genes mediating plant-pathogen interactions in a tree. Proc. Natl. Acad. Sci. USA 115: 11573-11578. PMID:30337484

C Voiniciuc, K Engle, M. Gunl, S Dieluweit, M Heinrich-Wilhelm, JY Yang, KW Moremen, KW Mohnen, D. Mohnen, B Usadel. 2018. Identification of Key Enzymes for Pectin Synthesis in Arabidopsis Seed Mucilage. Plant Physiol 178: 1045-1064. PMID:30228108

H Qiu, S Shi, J Yue, M Xin, AV Nairn, L Lin, X Liu, G Li, SA Archer-Hartmann, M Dela Rosa, M Galizi, S Wang, F Zhang, P Azadi, TH van Kuppevelt, WV Cardoso, K Kimata, X Ai, KW Moremen, J Esko, RJ Linhardt, L Wang. 2018. A mutant cell library for systematic analysis of heparan sulfate. Nature Meth 15: 889-899. PMID:30377379

SH Yu, P Zhao, PK Prabakhar, T Sun, A Beedle, GJ Boons, KW Moremen, L Wells, R Steet. 2018. Defective mucin-type glycosylation on alpha-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases. J. Biol. Chem. 293: 14534-14544. PMID:30049793

D Thieker, Y Xu, D Chapla, C Nora, H Qiu, T Felix, L Wang, KW Moremen, J Liu, J Esko, RJ Woods. 2018. Downstream products are potent inhibitors of the heparan sulfate 2-O-sulfotransferase . Scientific Reports 8: 11823-. PMID:30087361

S.M. Halmo, D. Singh, S. Patel, S. Wang, M. Edlin, G.J. Boons, K.W. Moremen, D. Live, L. Wells. 2017. Protein O-linked mannose beta-1,4-N-acetyglucosaminyltransferase 2 (POMGNT2) is a gatekeeper enzyme for functional glycosylation of alpha-dystroglycan. J. Biol. Chem. 292(6): 2101-2109. PMID:27932460

AR Prudden, L Liu, CJ Capicciotti, MA Wolfert, S Wang, Z Gao, L Meng, KW Moremen, GJ Boons. 2017. Synthesis of asymmetrical multiantennary human milk oligosaccharides. Proc Natl Acad Sci USA 114(27): 6954-6959. PMID:28630345

MO Sheikh, SM Halmo, S. Patel, D Middleton, H. Takeuchi, CM Schafer, CM West, RS Haltiwanger, FYI Avci, KW Moremen, L. Wells. 2017. Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases. Glycobiology Mar 1; 27(3): 206-212. PMID:28177478

S.T. Tuomivaara, P. Schliekelman, A.V. Nairn, K.W. Moremen, W.S. York. 2017. RElative QUantitation Inferred by Evaluating Mixtures (REQUIEM). Anal. Chim. Acta 993: 22-37. PMID:29078952

B.R. Urbanowicz, V.S. Bharadwaj, M. Alahuhta, M.J. Pena, V.V. Lunin, Y.J. Bomble, S. Wang, J.Y. Yang, S.T. Tuomivaara, M.E. Himmel, K.W. Moremen, W.S. York, M.F. Crowley. 2017. Structural, mutagenic and in silico studies of xyloglucan fucosylation in Arabidopsis thaliana suggest a water-mediated mechanism. Plant J. 91: 931-949. PMID:28670741

E Benedetti, M Pucic-Bakovic, T Keser, A Wahl, H Hassinen, I Trbojevic Akmacic, M Vila, GJ Razdorov, J Stambuk, L Klaric, I Ugrina, M Selman, M Wuhrer, I Rudan, O Polasek, C Carolina Hayward, H Grallert, K Strauch, A Peters, T Meitinger, C Gieger, J-Y Yang, L Lui, G-J Boons, S Kellokumpu, KW Moremen, N Bovin, FJ Theis, G Lauc, J Krumsiek. 2017. Network inference from glycoproteomics data reveals new reactions in the IgC glycosylation pathway. Nat Commun 8: 1483-. PMID:29440641

W Tong, CA Dwyer, BE Thacker, Glass, JR Brown, K Hamil, KW Moremen, S Sarrazin, PLSM Gordts, L Dozier, GN Patrick, Y Tor, JD Esko. 2017. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Molecular Therapy 25: 2743-2752. PMID:28958576

MS Hanges, KW Moremen, RD Cummings. 2017. Biochemical characterization of functional domains of the chaperone Cosmc. PLoS One 12:e0180242: -. PMID:28665962

Q Gao, GR Chalmers, KW Moremen, JH Prestegard. 2017. NMR Assignments of Sparsely Labeled Proteins Using a Genetic Algorithm. J Biomolecular NMR 67: 283-294. PMID:28289927

H Guo, B Zhang, A Nairn, T Nagy, KW Moremen, P Bukhaults, M Pierce. 2017. O-GlcNAc expression levels epigenetically regulate colon cancer tumorigenesis by affecting the cancer stem cell compartment via modulating expression of transcriptional factor MYBL1. J Biol Chem 292: 4123-4137. PMID:28096468

S-H Yu, P Zhao, T Sun, Z Gao, KW Moremen, GJ Boons, L Wells, R Steet. 2016. Selective exo-enzymatic labeling detects increased cell surface sialoglycoprotein expression upon megakaryocytic differentiation. J. Biol. Chem. 291(8): 3982-3989. PMID:26733198

T Sun, Yu S-H, P Zhao, L Meng, KW Moremen, L Wells, R Steet, GJ Boons. 2016. One-step selective exoenzymatic labeling (SEEL) strategy for the biotinylation and identification of glycoproteins of living cells. J Am Chem Soc 138(36): 11575-11582. PMID:27541995

C. Zong, R. Huang, E. Condac, Y Chiu, W.Y. Xiao, X. Li, W Lu, M Ishahara, S. Wang, A. Ramiah, M Stickney, P. Azadi, IJ Amster, KW Moremen, L. Wang, JS Sharp, GJ Boons. 2016. Integrated approach to identify heparan sulfate ligand requirements of Robo1. J Am Chem Soc 138(39): 13059- 13067. PMID:27611601

Q Gao, C-Y Chen, CT Zong, S. Wang, A. Ramiah, P Prabhakar, L.C. Morris, GJ Boons, K. Moremen, J.H. Prestegard. 2016. Structural aspects of heparan sulfate binding to Robo1-lg1-2. ACS Chem Biol 11(11): 3106-3113. PMID:27653286

T Li, M Huang, L Liu, S Wang, KW Moremen, GJ Boons. 2016. Divergent chemoenzymatic synthesis of asymmetrical core fucosylated and core-unmodified N-glycans. Chem - Eur J 22(52): 18742-18746. PMID:27798819

JL Praissman, T Willer, MO Sheikh, A Toi, D Chitayat, YY Lin, H Lee, SH Stalnaker, S Wang, PK Prabhakar, SF Nelson, DL Stemple, SA Moore, KW Moremen, KP Campbell, L Wells. 2016. The functional O-manose glycan on alpha-dystroglycan contains a phospho-ribitol primed for matriglycan addition. eLife Apr 29:5: pii: e14473-doi:10.7554/eLif. PMID:27130732

SH Yu, P Zhao, T Sun, Z Gao, KW Moremen, GJ Boons, L Wells, R Steet. 2016. Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression upon Megakaryocytic Differentiation. J Biol Chem 29(18): 3982-3989. PMID:26733198

Y Zhuo, JY Yang, KW Moremen, JH Prestegard. 2016. Glycosylation Alters Dimerization Properties of a Cell-surface Signaling Protein, Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 (CEACAM1). J Biol Chem 291: 20085-20095. PMID:27471271

Y Xiang, KW Karaveg, KW Morement. 2016. Substrate recognition and catalysis by GH47 a-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway. Proc Natl Acad Sci USA 113: E7890-E7899. PMID:27856750

K Aoki-Kinoshita, S Agravat, NP Aoki, S Arpinar, RD Cummings, A Fujita, N Fujita, GM Hart, SM Haslam, T Kawasaki, M Matsubara, KW Moremen, S Okuda, M Pierce, R Ranzinger, T Shikanai, D Shinmachi, E Solovieva, Y Suzuki, S Tsuchiya, I Yamada, WS York, J Zaia, H Narimatsu. 2016. GlyTouCan 1.0--The international glycan structure repository. Nucleic Acids Res 44: D1237-D1242. PMID:26476458

A Deligny, T Dierker, A Dagalv, A Lundequist, I Eriksson, AV Nairn, KW Moremen, CRL Merry, L Kjellen. 2016. NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length. J Biol Chem 291: 18600-18607. PMID:27387504

C Zhang, T Zhang, J Zou, CJ Miller, R Gorkhali, J-Y Yang, A Schilmiller, S Wang, K Huang, EM Brown, KW Moremen, J Hu, JJ Yang. 2016. Structural Basis for Regulation of Human Calcium-Sensing Receptor by Magnesium Ions and an Unexpected Tryptophan Derivative Co-agonist. Science Advances 2:1600241: -. PMID:27386547

B McMorran, F McCarthy, E Gibbs, M Pang, J Marshall, A Nairn, KW Moremen, R Crosbie-Watson, L Baum. 2016. Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx. Glycobiology 26: 1120-1132. PMID:27236198

R Berger, YH Sun, M Kulik, JK Lee, A Nairn, KW Moremen, M Pierce, S Dalton. 2016. ST8SlA4-dependent polysialylation is a part of a developmental program required for germ layer formation from human pluripotent stem cells. Stem Cells 34: 1742-1752. PMID:27074314

L Revoredo, S Wang, EP Bennett, H Clausen, KW Moremen, DL Jarvis, K Ten Hagen, LA Tabak, TA Gerken. 2016. Mucin Type O-Glycosyation is Controlled by Short and Long Range Glycopeptide Substrate Recognition that Varies Among Members of the Polypeptide GalNAc Transferase (ppGalNAc-T) Family. Glycobiology 26: 360-376. PMID:26610890

C Bello, S. Wang, L. Meng, KW Moremen, CFW Becker. 2015. A PEGylated Photocleavable Auxilary Mediates the Site-Specific Glycosylation and Native Chemical Ligation of Peptides. Angew Chem Int Ed 54: 7711-7715. PMID:25980981

Z. Liz, HA Moniz, A. Ramiah, KW Moremen, JS Sharp. 2015. High Structural Resolution Hydroxyl Radical Protein Footprinting Reveals an Extended Robo-1-Heparin Binding Interface. J. Biol. Chem. 290: 10729-10740. PMID:25752613

GP Subedi, H Moniz, RW Johnson, KW Moremen, AW Barb. 2015. High yield expression of recombinant human proteins with the transient transfection of HEK293 cells in suspension. J Vis Exp 106:e53568: -. PMID:26779721

T Zhou, DA Frabutt, KW Moremen, Y-H Zheng. 2015. ERMani is required for HIV-1 envelope glycoprotein degradation via endoplasmic reticulum-associated protein degradation pathway. J Biol Chem 290: 22184-22192. PMID:26205822

A Magalhaes, R Marcos-Pinto, AV Nairn, M dela Rosa, RM Ferreira, S Junqueira-Neto, D Freitas, J Gomes, P Oliveira, MR Santos, NT Marcos, W Xiaogang, C Figueiredo, C Oliveira, M Dinis-Ribeiro, Carneiro, KW Moremen, L David, CA Reis. 2015. Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways. Biochem Biophys Acta 1852: 1928-1939. PMID:26144047

F. Zhang, HA Moniz, E. Condac, KW Moremen, L. Wang, RJ Linhardt. 2014. Impact of GFP tagging on Robo1-heparin interactions. Biochem Biophys Res Comm 31: 299-307. PMID:24748467

B. Zhang, W.Y. Xiao, H. Qiu, F. Zhang, HA Moniz, A Jaworski, E. Condac, G. Gutierrez-Sanchez, C. Heiss, RD Clugston, P. Azadi, JJ Greer, C. Bergmann, KW Moremen, D. Li, RJ Linhardt, JD Esko, L Wang. 2014. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J. Clin. Invest. 124(1): 209-221. PMID:24355925

F Zhang, HA Moniz, B Walcott, KW Moremen, L Wang, RJ Linhardt. 2014. Probing the impact of GFP tagging on Robo1-heparin interaction.. Glycoconj. J. 31(4): 299-307. PMID:2014

JH Prestegard, DA Agard, KW Moremen, LA Lavery, LC Morris, K Pederson. 2014. Sparse labeling of proteins: structural characterization from long range constraints.. Magn Reson 241: 32-40. PMID:24656078

L Gasimli, AM Hickey, B Yang, G Li, M dela Rosa, AV Nairn, MJ Kulik, JS Dordick, KW Moremen, S Dalton, RJ Linhardt. 2014. Changes in glycosaminoglycan structure on differentiation of human embryonic stem cells towards mesoderm and endoderm lineages. Biochim Biophys Acta 1840(6): 1993-2003. PMID:24412195

JL Praissman, DH Live, S. Wang, A. Ramiah, ZS Chinoy, GJ Boons, KW Moremen, L. Wells. 2014. B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of alpha-dystroglycan.. eLife Oct 3;3: doi:10.7554/-eLife.03943. PMID:25279697

B.R. Urbanowicz, M.J. Pena, H.A. Moniz, K.W. Moremen, W.S. York. 2014. Two Arabidopsis proteins synthesize acetylated xylan in vitro. Plant J. 80: 197-206. PMID:25141999

C Zhang, Y Zhuo, HA Moniz, S Wang, KW Moremen, JH Prestegard, EM Brown, JJ Yang. 2014. Direct determination of multiple ligand interactions with the extracellular domain of the calcium-sensing receptor. J Biol Chem 289: 33529-33542. PMID:25305020

N.E. Mbua, X. Li, H.R. Flanagan-Steet, L. Meng, K. Aoki, K.W. Moremen, M.A. Wolfert, R. Steet, G.J. Boons. 2013. Selective exo-enzymatic labeling (SEEL) of N-glycans of living cells by recombinant ST6Gal. . Angewandte 52: 13012-13015. PMID:24129959

B. Zhang, W.Y. Xiao, H. Qiu, F.M. Zhang, H.A. Moniz, E. Condac, G. Gutierrez-Sanchez, C. Heiss, R.D. Clugston, P. Azadi, J.J. Greer, C. Bergmann, K.W. Moremen, D. Li, R.J. Linhardt, J.D. Esko, L. Wang. 2013. Congenital diaphragmatic hernia results from disruption of developmental angiogenesis mediated by Slit3-Robo4-heparan sulfate signaing. J. Clin. Invest. In press.

F.M. Zhang, H.A. Moniz, R.B. Walcott, K.W. Moremen, R.J. Linhardt, L. Wang. 2013. Characterization of the interaction between Robo1 and heparin and other glycosaminoglycans. Biochimie. 95(12): 2345-2353. PMID:23994753

L. Meng, F. Forouhar, D. Thieker, Z. Gao, A. Ramiah, H.A. Moniz, J. Seetharaman, S. Milaninia, M. Su, R. Bridger, L. Veillon, P. Azadi, G. Kornhaber, L. Wells, G.T. Montelione, R.J. Woods, L. Tong, K.W. Moremen. 2013. Enzymatic basis for N-glycan sialylation: Structure of mammalian alpha2,6-sialytransferase (ST6GAL1) reveals conserved and unique features for glycan sialytion. J. Biol. Chem. 288(48): 34680-34698. PMID:24155237

TA Gerken, L. Revoredo, JJC Thome, LA Tabak, MB Vester-Christensen, H. Clausen, GK Gahlay, DL Jarvis, RY Johnson, HA Moniz, KW Moremen. 2013. The lectin domain of the polypeptide GalNAc transferase family of glycosyltransferases (ppGalNAc Ts) acts as a switch directing glycopeptide substrate glycosylation in an N- or C-terminal direction, further controlling mucin type O-glycosylation. J. Biol. Chem. 288: 19900-19914. PMID:23689369

S Natunen, M Lampinen, H Suila, I Ritamo, V Pitkanen, AV Nairn, J Rabina, S Laitinen, KW Moremen, W Reutter, L Valmu. 2013. Metabolic glycoengineering of mesenchymal stromal cells with N-propanoylmannosamine. Glycobiology 23: 1004-1012. PMID:23708401

L Gasimli, HE Stansfield, AV Nairn, H Liu, JL Paluh, B Yang, JS Dordick, KW Moremen, RJ Linhardt. 2013. Structural remodeling of proteoglycans upon retinoic acid-induced differentiation of NCCIT cells. Glycoconj J 30: 497-510. PMID:23053635

P. Zhao, A.V. Nairn, S. Hester, K.W. Moremen, R.M. ORegan, G. Oprea, L. Wells, M. Pierce, K.L. Abbott. 2012. Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breat carcinoma. J.Biol Chem. 287: 25230-25240. PMID:22654114

A.W. Barb, L. Meng, Z. Gao, R.W. Johnson, K.W. Moremen, J.H. Prestegard. 2012. NMR charcterization of immunoglobulin G Fc Glycan motion on enzymatic sialylation. Biochemistry 51: 4618-4626. PMID:22574931

D.C. Kraushaar, S. Rai, E. Condac, A.V. Nairn, S. Zhang, Y. Yamaguchi, K. Moremen, S. Dalton, L. Wang. 2012. Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem calls. J. Biol. Chem. 287: 22691-22700. PMID:22556407

A.V. Nairn, K. Aoki, M. Dela, M. Porterfield, J.M. Lim, M. Kulik, J.M. Pierce, L. Wells, S. Dalton, M. Tiemeyer, K.W. Moremen. 2012. Regulation of glycan structures in murine embryonic stem cells: Combined transcript profiling of glycan-related genes and glycan structural analysis. J. Biol. Chem. 287: 37835-37856. PMID:22988249

K.W. Moremen, M. Tiemeyer, A.V. Nairn. 2012. Vertebrate protein glycosylation: diversity, synthesis and function. Nat. Rev. Mol. Cell Biol. 13: 448-462. PMID:22722607

H.B. Guo, A. V. Nairn, M. Dela Rosa, T. Nagy, S. Zhao, K. Moremen, M. Pierce. 2012. Transcriptional regulation of the protocadherin beta cluster during Her-2 induced mammary tumorigenesis results from alter N-glycan branching. J. Biol. Chem. 287: 24941-24954. PMID:22665489

A.C. Petrey, H. Flanagan-Steet, S. Johnson, X. Fan, M. Dela Rosa, M.E. Haskins, A.V. Nairn, K.W. Moremen, R. Steet. 2012. Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II. . Dis Model Mech 5: 177-190. PMID:22046029

WC Lamanna, R Lawrence, S Sarrazin, C Lameda-Diaz, PLSM Gordts, KW Moremen, JD Esko, . 2012. A Genetic Model of Substrate Reduction Therapy for Mucopolysaccharidosis. J Biol Chem 287: 36283-36290. PMID:22952226

S Pan, S Wang, B Utama, L Huang, N Blok, MK Estes, KW Moremen, RN Sifers. 2011. Golgi localization of ERManl defines spatial separation of the mammalian glycoprotein quality control system. Mol Biol Cell 22: 2810-2822. PMID:21697506

MA Rafiq, AW Kuss, L Puettmann, A Noor, A Ramiah, G Ali, HW Hu, NA Kerio, Y Xiang, M Garshasbi, MA Khan, GE Ishak, R Weksberg, R Ullmann, A Tzschach, K Kahrizi, K Mahmood, F Naeem, M Ayub, KW Moremen, JB Vincent, JB Ropers, M Ansar, H Najmabadi. 2011. Mutations in the alpha1,2-mannosidase gene, MAN1B1, cause autosomal recessive intellectual disability. Amer J Human Genet 15: 176-182. PMID:21763484

H. Park, C.A. Haynes, A.V. Nairn, M. Kulik, S. Dalton, K. Moremen, A.H. Merrill. 2010. Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. J. Lipid Res. 51: 480-489. PMID:19786568

Y. Zhu, M.D. Suits, A.J. Thompson, S. Chavan, Z. Dinev, C. Dumon, N.L. Smith, K. Moremen, Y. Xiang, A. Siriwardena, S.J. Williams, H.J. Gilbert, G.J. Davies. 2010. Mechanistic insights into a Ca2+-dependent family of a-mannosidases in a human gut symbiont. Nature Chem. Biol. 6: 125-132. PMID:20081828

AV Nairn, M dela Rosa, KW Moremen. 2010. Transcript Analysis in Stem Cells. Meth Enzymol 479: 79-91. PMID:20816160

R. Orlando, J.M. Lim, J.A. Atwood, P.M. Angel, M. Feng, G. Alvarez-Manilla, K.W. Moremen, W.S. York, M. Tiemeyer, J.M. Pierce, S. Dalton, R.L. Wells. 2009. IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J. Proteome Res. 8: 3816-3823. PMID:19449840

D.J. Termine, K.W. Moremen, R.N. Sifers. 2009. The mammalian UPR boosts glycoprotein ERAD by suppressing the down-regulation of ER mannosidase I. J. Cell Sci. Suppl. 22: 976-984. PMID:19258393

S Liu, L Meng, KW Moremen, JH Prestegard. 2009. NMR structural characterization of substrates bound to the alpha-2,66-sialytransferase, ST6Gal-l. Biochemistry 48: 11211-11219. PMID:19845399

H.B. Guo, A. Vandersall-Nairn, K. Harris, M. Randolph, G. Alvarez-Manilla, K. Moremen, M. Pierce. 2008. Loss of expression of N-acetylglucosaminyltransferase Va results in altered gene expression of glycosyltransferases and galectins. FEBS Lett. 582: 527-535. PMID:18230362

W.E. Zhong, D.A. Kuntz, B. Ember, H. Singh, K.W. Moremen, D.R. Rose, G.-J. Boons. 2008. Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J. Am. Chem. Soc. 130: 8975-8983. PMID:18558690

K.L. Abbott, A.V. Nairn, E.M. Hall, M.B. Horton, J.F. McDonald, K.W. Moremen, D.M. Dinulescu, M. Pierce. 2008. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics 8: 3210-3220. PMID:18690643

A.V. Nairn, W.S. York, K. Harris, E.M. Hall, J.M. Pierce, K.W. Moremen. 2008. Regulation of glycan structures in animal tissues: transcript profiling of glycan-related genes. J. Biol. Chem. 283: 17298-17313. PMID:18411279

M.A. Macnaughtan, F. Tian, S. Liu, L. Meng, S. Park, P. Azadi, K.W. Moremen, J.H. Prestegard. 2008. 13C-cialic acid labeling of glycans on glycoproteins using ST6Gal-1. J. Am Chem. Socl 130: 11864-11865. PMID:18700760

DJ Termine, KW Moremen, RN Sifers. 2008. The mammalian UPR boosts glycoprotein ERAD by suppressing the down-regulation of ER mannosidase l. J Cell Sci 122: 976-984. PMID:19258393

S. Liu, A. Venot, L. Meng, F. Tian, K.W. Moremen, G.J. Boons, J.H. Prestegard. 2007. Spin-labeled analogs of CMP-NeuAc as NMR probes of the alpha-2-6-sialyltransferase ST6Gal I. Curr. Opinion Chem. Biol. 14: 409-418. PMID:17462576

Y. Wu, D.J. Termine, M.T. Swulius, K.W. Moremen, R.N. Sifers. 2007. Human endoplasmic reticulum mannosidase I is subject to regulated proteolysis. J. Biol. Chem. 282: 4841-4849. PMID:17166854

A.V. Nairn, A. Kinoshita-Toyoda, H. Toyoda, J. Xie, K. Harris, S. Dalton, M. Kulik, J.M. Pierce, T. Toida, K.W. Moremen, R.J. Linhardt. 2007. Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J. Proteome Res. 6: 4374-4387. PMID:17915907

T.O. Akama, H. Nakagawa, N.-K. Wong, M. Sutton-Smith, A. Dell, J. Nakyama, S. Nishimura, A. Pai, K.W. Moremen, J.D. Marth, M.N. Fukuda. 2006. Essential and mutually compensatory roles of a-mannosidase and a-mannosidase IIx in N-glycan processing in vivo in mice. Proc. Natl. Acad. Sci. USA 103: 8983-8988. PMID:16754854

S.W. Mast, K.W. Moremen. 2006. Family 47 a-mannosidases in N-glycan processing. Methods Enzymol. 415: 31-46. PMID:17116466

K.W. Moremen, M. Molinari. 2006. N-linked glycan recognition and processing: the molecular basis of endoplasmic reticulum quality control. Curr. Opin. Struct. Biol. 16: 592-599. PMID:16938451

S.W. Mast, K. Diekman, K. Karaveg, A. Davis, R.N. Sifers, K.W. Moremen. 2005. Human EDEM2, a novel homolog of family 47 glycosidases, is involved in the ER-associated degradation of glycoproteins. Glycobiology 15: 421-436. PMID:15537790

K. Karaveg, A. Siriwardena, W. Tempel, Z.-J. Liu, J. Glushka, B.-C. Wang, K.W. Moremen. 2005. Mechanism of Class 1 (glycosylhydrolase family 47) a-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control. J. Biol. Chem. 280: 16197-16207. PMID:15713668

A. Siriwardena, H. Strachan, S. El-Daher, G. Way, B. Winchester, J. Glushka, K. Moremen, G.J. Boons. 2005. Potent and selective inhibition of Class II a-D-mannosidase activity by a bicyclic sulfonium salt. Chembiochem. 6: 845-848. PMID:15800866

K. Karaveg, K.W. Moremen. 2005. Energetics of substrate binding and catalysis by Class 1 (glycosylhydrolase family 47) a-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control. J. Biol. Chem. 280: 29837-29848. PMID:15911611

C.T. Park, L. Meng, L.H. Stanton, R.E. Collins, S.W. Mast, X. Yi, H. Strachan, K.W. Moremen. 2005. Characterization of a human core-specific lysosomal a1,6-mannosidase involved in N-glycan catabolism. J. Biol. Chem. 280: 37204-37216. PMID:16115860

K.W. Herring, K. Karaveg, K.W. Moremen, W.H. Pearson. 2005. A practical synthesis of kifuensine analogues as inhibitors of endoplasmic reticulum a-mannosidase I. J. Org. Chem. 70: 9892-9904. PMID:16292820

J.K. Lee, L.G. Baum, K. Moremen, M. Pierce. 2004. The X-lectins: A new family with homology to the Xenopus laevis oocyte lectin XL-35. Glycoconjugate J. 21: 443-450. PMID:15750785

W. Tempel, K. Karaveg, Z.J. Liu, J.K.C. Rose, B.C. Wang, K.W. Moremen. 2004. Structure of mouse Golgi alpha-mannosidase IA reveal the molecular basis for stubstrate specificity among class 1 (family 47 blycosylhydrolase) alpha,2-mannosidases. J. Biol. Chem. 279: 29774-29784. PMID:15102839

B. Li, S.P. Kawatkar, G.S. Strachan, H. Strachan, R.J. Woods, A. Siriwardena, K.W. Moremen, G.J. Boons. 2004. Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Chem. BioChem. 5: 1220-1227. PMID:15368573

Y. Wu, K.W. Moremen, R.N. Sifers. 2003. Elucidation of the molecular logic that preferentially targets misfolded alpha1-antitrypsin for intracellular degradation. Proc. Natl. Acad. Sci. USA 100: 8229-8234. PMID:12815101

M. Kaneko, M. Kamar, W.-J. Zhang, J.-K. Lee, K. Moremen, M. Pierce. 2003. A novel N-acetylglucosaminyltransferase, GnT-VB, that synthesizes N-linked b(1,6) branched glycans. FEBS Lett. 554: 515-519. PMID:14623122

T.O. Akama, H. Nakagawa, K. Sugihara, S. Narisawa, C. Ohyama, S. Nishimura, D.A. O'Brien, K.W. Moremen, J.L. Millan, M.N. Fukuda. 2002. Germ cell survival through carbohydrate-mediated interaction with Sertoli cells. Science 295: 124-127. PMID:11778047

C.M. Cabral, Y. Liu, K.W. Moremen, R.N. Sifers. 2002. Organizational diversity among distinct glycoprotein ER-associated degradation programs. Mol. Biol. Cell 13: 2639-2650. PMID:12181335

K. Moremen. 2002. Golgi a-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals. Biochem. Biophys. Acta. 1573: 225-235. PMID:12417404

J.-K. Lee, M. Pang, J. Schnee, L. Baum, K. Moremen, M. Pierce. 2001. Human homologs of the Xenopus oocyte cortical granule lectin XL35. Glycobiology 11: 65-73. PMID:11181563

M. Oh-Eda, H. Nakagawa, T.O. Akayama, K. Lowitz, M. Misago, K.W. Moremen, M.N. Fukuda. 2001. Overexpression of the Golgi-localized enzyme a-mannosidase IIx in Chinese hamster ovary cells results in the conversion of hexamannosyl-N-acetylchitobiose to tetramannoseyl-N-acetylchitobiose in the N-glycan processing pathway. Eur. J. Biochem. 268: 1280-1288. PMID:11231279

C.A. Rivera-Marrero, J.D. Ritzenthaler, J. Roman, K.W. Moremen. 2001. Molecular cloning and expression of an a-mannosidase gene in Mycobacterium tuberculosis. Microbiol. Pathog. 30: 9-18. PMID:11162181

Z. Kawar, K. Karaveg, K.W. Moremen, D.L. Jarvis. 2001. Insect cells encode a class II alpha-mannosidase with unique properties. J. Biol. Chem. 276: 16335-16340. PMID:11279010

F. VAllee, K. Karaveg, A. Herscovics, K.W. Moremen, P.L. Howell. 2000. Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2,-mannosidases. J. Biol. Chem. 275: 41287-41298. PMID:10995765

D.S. Gonzalez, Y. Kagawa, K.W. Moremen. 1999. Isolation and characterization of the gene encoding the mouse broad specificity lysosomal alpha-mannosidase. Biochim. Biophys. Acta 1445: 177-183. PMID:10209272

D.S. Gonzalez, K. Karaveg, A.S. Vandersall-Nairn, A. Lal, K.W. Moremen. 1999. Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. J. Biol. Chem. 274: 21375-21386. PMID:10409699

F. Valee, A. Lal, K.W. Moremen, P.L. Howell. 1999. Purification, crystallization and preliminary X-ray crystallographic analysis of recombinant murine Golgi mannosidase IA, a Class I alpha-mannosidase involved in Asn-linked oligosaccharide maturation. Acta Crystallog. D55: 571-573.

S.A. Igdoural, A. Herscovics, A. Lal, K.W. Moremen, C.R. Morales, L. Hermo. 1999. a-Mannosidases involved in N-glycan processing show cell specificity and distinct subcompartmentalization with the Golgi apparatus of cells in the testis and epididymus. Eur. J. Cell Biol. 78: 441-452. PMID:10472797

S Di Virgilio, J Glushka, KW Moremen, M Pierce. 1999. Enzymatic synthesis of natural and 13C enriched linear poly-N-Acetyllactosamines as ligands for galectin-1. Glycobiology 9: 353-364. PMID:10089209

A. Lal, P. Pang, S. Kalelkar, P.A. Romero, A. Herscovics, K.W. Moremen. 1998. Substrate specificities of recombinant murine Golgi a-1,2-mannosidases IA and IB and comparison with endoplasmic reticulum and Golgi processing a-1,2-mannosidases. Glycobiology 8: 981-995. PMID:9719679

A. Vandersall-Nairn, K. O'Brien, R.K. Merkle, T.N. Oeltmann, K.W. Moremen. 1998. Cloning, expression, purification, and characterization of the acid alpha-mannosidase from Trypanosoma cruzi. Glycobiology 8: 1183-1194. PMID:9858640

D. Chui, M. Oh-Eda, Y.-F. Liao, K. Panneerselvam, A. Lal, W.W. Marek, H.H. Freeze, K.W. Moremen, M.N. Fukuda, J.D. Marth. 1997. Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell 90: 157-167. PMID:9230311

S. Howard, C. Braun, J. McCarter, K.W. Moremen, Y.-F. Liao, S.G. Withers. 1997. Human lysosomal and jack bean a-mannosidases are retaining glycosidases. Biochem. Biophys. Res. Commun. 238: 896-898. PMID:9325188

J.-K. Lee, P. Buckhaults, C. Wilkes, M. Teilhet, K. Moremen, M. King, M. Pierce. 1997. Cloning and expression of the Xenopus laevis oocyte lectin and characterization of its mRNA levels during early development. Glycobiology 7: 367-372. PMID:9147045

R.K. Merkle, Y. Zhang, P.J. Ruest, A. Lal, Y.-F. Liao, K.W. Moremen. 1997. Cloning, expression, purification, and characterization of the murine lysosomal acid a-mannosidase. Biochim. Biophys. Acta 1336: 132-146. PMID:9305783

D.L. Jarvis, D.A. Bohlmeyer, Y.-F. Liao, K.K. Lomax, R.K. Merkle, K.W. Moremen. 1996. Isolation and characterization of a class II a-mannosidase cDNA from lepidopteran insect cells. Glycobiology 7: 113-127.

Y.-F. Liao, A. Lal, K.W. Moremen. 1996. Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid a-mannosidase. J. Biol. Chem. 271: 28348-28358. PMID:8910458

M. Misago, Y.-F. Liao, S. Kudo, M.-G. Mattei, K.W. Moremen, M.N. Fukuda. 1995. Molecular cloning and expression of cDNAs encoding human a-mannosidase II and a novel a-mannosidase IIx isozyme. Proc. Natl. Acad. Sci. USA 92: 11766-11770. PMID:8524845

P.A. Prieto, P. Mukerjit, B. Kelder, R. Erney, D. Gonzalez, J.S. Yun, D.F. Smith, K.W. Moremen, C. Nardelli, M. Pierce, Y. Li, X. Chen, T.E. Wagner, R.D. Cummings, J.J. Kopchick. 1995. Remodeling of mouse milk glycoconjugates by transgenic expression of a human glycosyltransferase. J. Biol. Chem. 270: 29515-29519.

A. Herscovics, J. Schneikert, A. Athanassiadis, K.W. Moremen. 1994. Isolation of a mouse Golgi mannosidase cDNA, a member of a gene family conserved from yeast to mammals. J. Biol. Chem. 269: 9872-9881.

A. Lal, J.S. Schutzbach, W.T. Forsee, P.J. Neame, K.W. Moremen. 1994. Isolation and expression of murine and rabbit a1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides. J. Biol. Chem. 269: 9864-9871.

K.W. Moremen, R.B. Trimble, A. Herscovics. 1994. Glycosidases of the asparagine-linked oligosaccharide processing pathway. Glycobiology 4: 113-125.

T. Oeltman, C. Carter, R. Merkle, K. Moremen. 1994. The a-mannosidase of Trypanosoma cruzi: structure and function. Braz. J. Med. Biol. Res. 27: 483-488.

C. Abeijon, K. Yanigasawa, E. Mandon, A. Hausler, K. Moremen, C.B. Hirschberg, P.W. Robbins. 1993. Guanosine diphosphatase is required for protein and lipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. J. Cell Biol. 122: 307-323.

R. Sasisekharan, M. Bulmer, K.W. Moremen, C.L. Cooney, R. Langer. 1993. Cloning and expression of heparinase I gene from Flavobacterium heparinum. Proc. Natl. Acad. Sci. USA 90: 3660-3664.

A. Velasco, K.W. Moremen, L. Hendricks, D.R.P. Tulsiani, O. Touster, M.G. Farquhar. 1993. Cell-type dependent variations in the subcellular distribution of a-mannosidase IA and II. J. Cell Biol. 122: 39-51.

K.W. Moremen, P.W. Robbins. 1991. Isolation, characterization, and expression of cDNA encoding murine a-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans. J. Cell Biol. 115: 1521-1534.

K.W. Moremen, P.W. Robbins, O. Touster. 1991. Novel purification of the catalytic domain of Golgi mannosidase II: Characterization and comparison with the intact enzyme. J. Biol. Chem. 266: 16876-16885.

C. Zuber, J. Roth, T. Mistelli, A. Nakano, K. Moremen. 1991. DS 28-6, a temperature-sensitive mutant of Chinese hamster ovary cells, expresses the key phenotypic changes associated with Brefeldin A treatment. Proc. Natl. Acad. Sci. USA 88: 9818-9822.

J. Bischoff, K.W. Moremen, H. Lodish. 1990. Isolation, characterization, and expression of a cDNA encoding the rat liver endoplasmic reticulum a-mannosidase. J. Biol. Chem. 265: 17110-17117.

M.N. Fukuda, K.A. Masri, A. Dell, L. Luzzato, K.W. Moremen. 1990. Incomplete synthesis of N-glycans in congenital dyserythropoetic anemia type II (HEMPAS) caused by a gene defect encoding a-mannosidase II. Proc. Natl. Acad. Sci. USA 87: 7443-7447.

K.W. Moremen. 1989. Isolation of a rat liver Golgi mannosidase II clone by mixed oligonucleotide-primed amplification of cDNA. Proc. Natl. Acad. Sci. USA 86: 5276-5280.

K.W. Moremen, O. Touster. 1986. Topology of mannosidase II in rat liver Golgi membranes and release of the catalytic domain by selective proteolysis. J. Biol. Chem. 261: 10945-10951.

K.W. Moremen, O. Touster. 1985. Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells. J. Biol. Chem. 260: 6654-6662.

Book Chapters

AV Nairn, KW Moremen. 2015. Glycotranscriptomics in Glycoscience: Biology and Medicine (N. Taniguchi, T. Endo, G. Hart, P. Seeberger, C.-H. Wang). In: , pp. 1475-1482. Springer-Verlag, Tokyo.

A.V. Nairn, K.W. Moremen. 2014. Glucosidase, alpha neutral AB; glucosidase II subunit beta (GANAB, PRKCSH, alpha-glucosidase II). In: Handbook of Glycosyltransferases and Related Genes, 2nd edition (Taniguchi N. ed), pp. 1283-1295. Springer-Verlag, Tokyo.

A.V. Nairn, K.W. Moremen. 2014. Mannosyl-oligosaccharide glucosidase (Glucosidase I, MOGS). In: Handbook of Glycosyltransferases and Related Genes, Vol.2nd edition:1273-1282. Springer-Verlag, Tokyo.

K.W. Moremen, A.V. Nairn. 2014. Mannosidase, alpha, class 2a1 (MAN2A1, Golgi alpha-mannosidase II). In: Handbook of Glycosyltransferases and Related Genes, 2nd edition, pp. 1313-1326. Springer-Verlag, Tokyo.

K.W. Moremen, A.V. Nairn. 2014. Mannosidase, alpha, class 1 (MAN1A1) (Golgi alpha-, class 1 (MAN1A1 (Golgi alpha-mannosidase 1A), Man1A2 (Golgi alpha-mannosidase 1B), MAN1B1 (ER alpha-mannosidase I), MAN1C1 (Golgi alpha-mannosidase 1C). In: Handbook of Glycosyltransferases and Related Genes, 2nd edition, pp. 1297-1312. Springer-Verlag, Tokyo.

A. Vandersall-Nairn, K. Moremen. 2009. Glycotranscriptomics. In: Handbook of Glycomics (R.D. Cummings and J.M. Pierce, eds.), pp. 81-136. Academic Press.

KW Moremen. 2002. alpha-Mannosidase ll . In: Handbook of Glycosyltransferases and Related Genes, pp. 600-606. Springer-Verlag, Tokyo.

K.W. Moremen. 2001. Mannosidases in asparagine-linked oligosaccharide processing and catabolism. In: Oligosaccharides in Chemistry and Biology: A Comprehensive Handbook, Vol II, Part 1 (B. Ernst, G.Hart, and P. Sindy, eds.), pp. 81-117. Wiley and Sons Publishers.

RB Trimble, KW Moremen, A Herscovics. 1994. Mannosidases of the Golgi Apparatus . In: Guidebook to the Secretory Pathway, pp. 185-188. Sambrook and Tooze Scientific Publishers.

RB Trimble, KW Moremen, A Herscovics. 1994. N-glycan processing in the endoplasmic reticulum. In: Guidebook to the Secretory Pathway, pp. 100-104. Sambrook and Tooze Scientific.

K.W. Moremen, O. Touster. 1987. Mannosidases in mammalian glycoprotein processing. In: Protein Transfer and Organelle Biogenesis (R.C. Das and P.W. Robbins, eds.), pp. 209-240. Academic Press.

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