CCRC NMR Facility

The CCRC NMR spectroscopy facility, under the direction of Prof. Arthur Edison, is used for a wide variety of biomolecular applications including metabolomics, determination of structures of carbohydrates, proteins and other molecules, as well as development of methods for studying protein-carbohydrate interactions. The CCRC NMR Facility consists of eight spectrometers ranging from 300MHz to 900MHz as well as an Oxford dissolution DNP system. Technical inquiries about the facility or NMR capabilities should be directed to John Glushka (, 706-542-4483). To initiate an analytical service contract, please contact Parastoo Azadi (, 706-542-0629). For research collaborations please see the list of NMR active laboratories below.

Description of Spectrometers

All spectrometers are equipped with Z-gradients and variable temperature control.

Field 300 500 600 600
console Varian/Agilent mercury Varian/Agilent Inova Varian/Agilent Vnmrs Varian/Agilent DD2
RF channels 2 3 3 4
Standard Probe 5mm BB (ATP) RT 8mm H{X} RT 5mm HCN coldprobe 3mm HCN coldprobe, carbon enhanced
Other probes, hardware   5mm HCN RT

HCN flow cell
5mm HCN RT

12 tube autosampler
3mm H{X} RT

Field 600 600* 800 900
Console Bruker Avance III Bruker Avance III Bruker Avance III Varian/Agilent DD2
RF channels 3 3 3 4
Standard probe 5mm TCI H-C/N-D cryoprobe 5mm DCH D/H-C

carbon cryoprobe
5mm TCI H-C/N-D cryoprobe 5mm HCN coldprobe, carbon enhanced
Other probes, hardware 5mm TXI S3 RT

HRMAS 1.7mm TCI cryoprobe*


*coming in 2017

Oxford Hypersense® dissolution DNP

An Oxford Hypersense dynamic nuclear polarizer is currently associated with the 500MHz spectrometer and is available for research projects. Please contact John Glushka for information.

Other laboratory facilities, software

Standard wet laboratory facilities and supplies are available for sample preparation. Workstations running VNMRJ, Topspin, MestreNova, NMRpipe, NMRViewJ and other software are available.

Facility Policies

NMR data can be obtained via a service or a collaborative arrangement with CCRC personnel, or directly by researchers after approval and adequate training on the spectrometers. Training will be provided free of charge on the 300MHz instrument and higher fields as necessary. We reserve the right to confer or rescind spectrometer privileges dependent on training level, time elapsed since last session, and treatment of the spectrometer. The qualified user will be able to reserve time using FACES, our web based scheduling program.

Charges for Use

Users will be charged for the time scheduled on the spectrometer. For service work or assistance, additional operator charges apply and a quote will be provided. For collaborative projects intended for co-authored publications, specific arrangements should be made with the appropriate CCRC faculty or staff member.

The following rates apply to samples of sufficient purity and amount, and with adequate supporting information (e.g. known literature data) for a straightforward analysis. Beyond simple 1D proton data, a typical sample might require a few 2D experiments and a day of analysis. More difficult samples will typically require an initial evaluation and some discussion of the cost estimate.  Sessions that require probe changes or additional hardware setup will be charged accordingly.

Spectrometer Rates ($US/Hr) peak/off-peak

Cost Category 300 500 600 800 900 DNP
Academic or non-profit $3.00 / $1.50 $6.00 / $3.00 $10.00 / $5.00 $12.00 / $6.00 $16.00 / $8.00 $16.00
corporate $7.50 $17.00 $30.00 $43.00 $83.00 $35.00

Corporate rates include operating costs, overhead and equipment amortization.

Non-profit rates only cover maintenance costs.

Operator Charges ( added to spectrometer charges)

Academic/non-profit $50.00/hour (minimum 1 hr)

Corporate $75.00/hour (minimum 1 hr)

Some Research Groups using NMR at CCRC

Research Group Areas of interest / expertise Contact
Art Edison

Professor, Eminent Scholar

Professor of Genetics, Biochemistry and Molecular Biology
Metabolomics, natural products and biological chemistry

James Prestegard

Professor of Biochemistry and Molecular Biology, and Chemistry
Structural Biology

Methods development for large glycoproteins and protein-carbohydrate interactions

William York

Professor of Biochemistry and Molecular Biology
Structural analysis of plant cell walls

Jeff Urbauer

Professor of Biochemistry and Molecular Biology, Chemistry
Structural biology; protein structure and dynamics

Arthur Roberts

Assistant Professor of Pharmaceutical and Biomedical Sciences
Interaction of drugs with multiple-drug resistance transporters.

Development of NMR methods.