Welcome to Dr. Mohnen's Lab webpage

(This website is a work in progress; please check back for updated news and links)

Our research goals are to understand the biosynthesis, structure and function of pectin; the architecture of plant walls; how their modification can yield enhanced biomaterials including biofuel; and the structure and function of pectins with anti-cancer activity.

Recent publications:

Hao Z, Avci U, Tan L, Zhu X, Glushka J, Pattathil S, Eberhard S, Sholes T, Rothstein GE, Lukowitz W, Orlando R, Hahn MG and Mohnen D (2014) Loss of Arabidopsis GAUT12/IRX8 causes anther indehiscence and leads to reduced G lignin associated with altered matrix polysaccharide deposition. Front. Plant Sci. 5:357. doi: 10.3389/fpls.2014.00357

Hao, Z. and Mohnen, D. (2014) A review of xylan and lignin biosynthesis: Foundation for studying Arabidopsis irregular xylem mutants with pleiotropic phenotypes. Crit. Rev. Biochem. Mol. Biol. 49(3):212-241. 

Mohnen, D. and Atmodjo, M.A. (2014), "Plant cell wall: structure and biosynthesis", in Pierce, M. (ed.), Glycobiology: The discovery of glycan function and its fundamental applications, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL1483649)

Atmodjo, M.A., Hao Z., Mohnen, D. (2013) Evolving Views of Pectin Biosynthesis. Annu. Rev Plant Biol. 64:28.1-28.33.

Tan, L., Eberhard, S., Pattathil, S., Warder, C., Glushka, J., Yuan, C., Hao, Z., Zhu, X., Avci, U., Miller, J.S., Baldwin, D., Pham, C., Orlando, R., Darvill, A., Hahn, M.G., Kieliszewski, M. and Mohnen, D. (2013) An Arabidopsis cell wall proteoglycan consists of pectin and arabinoxylan covalently linked to an arabinogalactan protein. Plant Cell 25(1):270-287.

Irina Kataeva,I., Foston, M., Yang,S.-J., Pattathil, S., Biswal, A.K., Poole II, F.L., Basen, M., Rhaesa, A.M., Thomas, T.P., Azadi, P., Olman, V., Scaffold, T.D., Mohler, K.E., Lewis, D.L., Doeppke,C., Zeng, Y., Tschaplinsky, T., York, W.S., Davis, M., Mohnen, D., Xu, Y., Ragauskas, A., Ding, S.-Y., Kelly, R.M., Hahn, M.G.,Adams, M.W.W. (2013) Carbohydrate and Lignin are Simultaneously Solubilized from Unpretreated Switchgrass by Microbial Action at High Temperature. Energy & Environmen. Sci. 6:2186-2195.

Kong, Y., Zhou, G, Abdeen, A.M.A., Schafhauser, J., Richardson, B., Atmodjo, M.A., Jung, J., Wicker, L., Mohnen, D., Western, T., and Hahn, M.G.(2013) AtGATL5 is Involved in the Production of Arabidopsis Seed Coat Mucilage. Plant Physiol. 163(3):1203-1217.

Atmodjo, M A., Sakuragi, Y., Zhu, X., Burrell,J.A., Mohanty, S.S., Atwood III, J.A., Orlando, R, Scheller, H.V. and Mohnen, D. (2011) GAUT1:GAUT7 are the core of a plant cell wall pectin biosynthetic homogalacturonan:galacturonosyltransferase complex. Proc. Natl. Acad. Sci. USA 108(50):20225-20230

Mohnen, D and Tierney, M. (2011) Plants get Hyp to O-glycosylation. (invited Perspective), Science 332(6063):1393-1394.

Yin,Y., Chen, H. Hahn, M.G., Mohnen, D. and Xu, Y.(2010). Evolution and function of the plant cell wall synthesis-related Glycosyltransferase Family 8. Plant Physiology. Published on June 3, 2010, as DOI:10.1104/pp.110.154229 2:1000-1014.

Yin, Y., Mohnen, D., Gelineo-Albersheim, I., Xu, Y., Hahn, M.G. Glycosyltransferases of  Family 8 (GT8).  In  Plant Cell Wall Polysaccharides: Biosynthesis and Bioengineering, Annual Plant Review series, Blackwell, Oxford, UK. (in press)

Caffal, H.K., Pattathil, S., Phillips, S.E., Hahn, M.G. and Mohnen, D. (2009) Arabidopsis thaliana T-DNA mutants implicate GAUT genes in the biosynthesis of pectin and xylan in cell walls and seed testa. Molecular Plant 2:1000-1014.

Singh, B., Avci, U., Inwood, S.E.E., Grimson,M.J., Landgraf, J., Mohnen, D., Sørensen, I., Wilkerson, C.G.W., Willats, W.G.T., and Haigler, C.H. (2009) A specialized primary wall layer conjoins cotton fibers into tissue-like bundles during elongation. Plant Physiology (Plant Physiol. 150(2):684-99.

Caffal, H.K. and Mohnen, D. (2009) The structure, function and biosynthesis of pectic polysaccharides in the context of the whole plant cell wall. Carbohydr. Res.  344:1879-1900. 

Mohnen, D. (2008) Pectin Structure and Synthesis. Curr. Opin. Plant Biology 11:266-277.

Mohnen, D., Bar-Peled, M. and Somerville, C. (2008) Biosynthesis of Plant Cell Walls.  In Biomass Recalcitrance, ed. Himmel, M.,Blackwell Publishing, Oxford. Chapter 5, pgs. 94-187.

Etzler, M.E. and Mohnen, D. (2008) Green Plants. In Essentials of Glycobiology, Second Edition, eds. Varki, A., Cummings, R., Esko, J., Freeze, H., Stanley, P., Bertozzi, C., Hart, G. and Etzler, M. Cold Spring Harbor Laboratory Press, Chapter 22.

Jackson, C.L., Dreaden, T.M., Theobald, L.K., Tran, N.M.; Beal, T.L., Eid, M., Gao, M.Y., Shirley, R.B., Stoffel, M.T., Kumar, M.V.  Mohnen, D.  (2007) Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiology 17:805-819.

Persson, S., Caffall, K.H., Freshour, G. Hilley, M.T., Bauer, S., Poindexter, P., Hahn, M., Mohnen, D., Somerville, C. (2007) The Arabidopsis irregular xylem 8 mutant is deficient in glucuronoxylan and homogalacturonan which are essential for secondary cell wall integrity. Plant Cell 19:237-255.

Sterling, J.D., Atmodjo, M.A., Inwood, S.E., Kolli, V.S.K., Quigley, H.F., Hahn, M.G., and Mohnen, D. (2006) Functional identification of an Arabidopsis pectin biosynthetic homogalacturonan galacturonosyltransferase. Proc. Natl. Acad. Sci. USA.103:5236-5241.

Mohnen research featured in 'Research Highlights' from the National Research Institutes. click here for pdf.

Please click here for additional publications from the Mohnen lab.